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Gut microbiota drives age-related oxidative stress and mitochondrial damage in microglia via the metabolite N6-carboxymethyllysine.
Nat Neurosci. 2022 Mar;25(3):295-305. doi: 10.1038/s41593-022-01027-3. Epub 2022 Mar 3.
Nat Neurosci. 2022.
PMID: 35241804
Microbiota-dependent increase in δ-valerobetaine alters neuronal function and is responsible for age-related cognitive decline.
Mossad O, Nent E, Woltemate S, Folschweiller S, Buescher JM, Schnepf D, Erny D, Staeheli P, Bartos M, Szalay A, Stecher B, Vital M, Sauer JF, Lämmermann T, Prinz M, Blank T.
Mossad O, et al. Among authors: szalay a.
Nat Aging. 2021 Dec;1(12):1127-1136. doi: 10.1038/s43587-021-00141-4. Epub 2021 Dec 20.
Nat Aging. 2021.
PMID: 37117525
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