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Page 1
BH3 mimetic drugs cooperate with Temozolomide, JQ1 and inducers of ferroptosis in killing glioblastoma multiforme cells.
Cell Death Differ. 2022 Jul;29(7):1335-1348. doi: 10.1038/s41418-022-00977-2. Epub 2022 Mar 24.
Cell Death Differ. 2022.
PMID: 35332309
Free PMC article.
Disordered clusters of Bak dimers rupture mitochondria during apoptosis.
Uren RT, O'Hely M, Iyer S, Bartolo R, Shi MX, Brouwer JM, Alsop AE, Dewson G, Kluck RM.
Uren RT, et al. Among authors: shi mx.
Elife. 2017 Feb 6;6:e19944. doi: 10.7554/eLife.19944.
Elife. 2017.
PMID: 28182867
Free PMC article.
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Structure of the BAK-activating antibody 7D10 bound to BAK reveals an unexpected role for the α1-α2 loop in BAK activation.
Robin AY, Miller MS, Iyer S, Shi MX, Wardak AZ, Lio D, Smith NA, Smith BJ, Birkinshaw RW, Czabotar PE, Kluck RM, Colman PM.
Robin AY, et al. Among authors: shi mx.
Cell Death Differ. 2022 Sep;29(9):1757-1768. doi: 10.1038/s41418-022-00961-w. Epub 2022 Mar 12.
Cell Death Differ. 2022.
PMID: 35279694
Free PMC article.
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Intact TP-53 function is essential for sustaining durable responses to BH3-mimetic drugs in leukemias.
Thijssen R, Diepstraten ST, Moujalled D, Chew E, Flensburg C, Shi MX, Dengler MA, Litalien V, MacRaild S, Chen M, Anstee NS, Reljić B, Gabriel SS, Djajawi TM, Riffkin CD, Aubrey BJ, Chang C, Tai L, Xu Z, Morley T, Pomilio G, Bruedigam C, Kallies A, Stroud DA, Bajel A, Kluck RM, Lane SW, Schoumacher M, Banquet S, Majewski IJ, Strasser A, Roberts AW, Huang DCS, Brown FC, Kelly GL, Wei AH.
Thijssen R, et al. Among authors: shi mx.
Blood. 2021 May 20;137(20):2721-2735. doi: 10.1182/blood.2020010167.
Blood. 2021.
PMID: 33824975
Free PMC article.
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Robust autoactivation for apoptosis by BAK but not BAX highlights BAK as an important therapeutic target.
Iyer S, Uren RT, Dengler MA, Shi MX, Uno E, Adams JM, Dewson G, Kluck RM.
Iyer S, et al. Among authors: shi mx.
Cell Death Dis. 2020 Apr 23;11(4):268. doi: 10.1038/s41419-020-2463-7.
Cell Death Dis. 2020.
PMID: 32327636
Free PMC article.
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A novel inhibitory BAK antibody enables assessment of non-activated BAK in cancer cells.
Subas Satish HP, Iyer S, Shi MX, Wong AW, Fischer KC, Wardak AZ, Lio D, Brouwer JM, Uren RT, Czabotar PE, Miller MS, Kluck RM.
Subas Satish HP, et al. Among authors: shi mx.
Cell Death Differ. 2024 Apr 6. doi: 10.1038/s41418-024-01289-3. Online ahead of print.
Cell Death Differ. 2024.
PMID: 38582955
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