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CRTC1 deficiency, specifically in melanocortin-4 receptor-expressing cells, induces hyperphagia, obesity, and insulin resistance.
FASEB J. 2022 Dec;36(12):e22645. doi: 10.1096/fj.202200617R.
FASEB J. 2022.
PMID: 36349991
Disruption of CRTC1 and CRTC2 in Sim1 cells strongly increases high-fat diet intake in female mice but has a modest impact on male mice.
Tanaka J, Ishikawa F, Jinno T, Miyakita M, Miyamori H, Sasaki T, Yokokawa T, Goto T, Inoue K, Matsumura S.
Tanaka J, et al. Among authors: miyamori h.
PLoS One. 2022 Jan 12;17(1):e0262577. doi: 10.1371/journal.pone.0262577. eCollection 2022.
PLoS One. 2022.
PMID: 35020776
Free PMC article.
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Stimulation of Gs signaling in MC4R cells by DREADD increases energy expenditure, suppresses food intake, and increases locomotor activity in mice.
Matsumura S, Miyakita M, Miyamori H, Kyo S, Shima D, Yokokawa T, Ishikawa F, Sasaki T, Jinno T, Tanaka J, Goto T, Momma K, Ishihara K, Berdeaux R, Inoue K.
Matsumura S, et al. Among authors: miyamori h.
Am J Physiol Endocrinol Metab. 2022 May 1;322(5):E436-E445. doi: 10.1152/ajpendo.00439.2021. Epub 2022 Mar 28.
Am J Physiol Endocrinol Metab. 2022.
PMID: 35344393
Free article.
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