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Discovery and Targeting of a Noncanonical Mechanism of Sarcoma Resistance to ADI-PEG20 Mediated by the Microenvironment.
Rogers LC, Kremer JC, Brashears CB, Lin Z, Hu Z, Bastos ACS, Baker A, Fettig N, Zhou D, Shoghi KI, Dehner CA, Chrisinger JSA, Bomalaski JS, Garcia BA, Oyama T, White EP, Van Tine BA. Rogers LC, et al. Among authors: brashears cb. Clin Cancer Res. 2023 Aug 15;29(16):3189-3202. doi: 10.1158/1078-0432.CCR-22-2642. Clin Cancer Res. 2023. PMID: 37339179 Free PMC article.
Malic Enzyme 1 Absence in Synovial Sarcoma Shifts Antioxidant System Dependence and Increases Sensitivity to Ferroptosis Induction with ACXT-3102.
Brashears CB, Prudner BC, Rathore R, Caldwell KE, Dehner CA, Buchanan JL, Lange SES, Poulin N, Sehn JK, Roszik J, Spitzer D, Jones KB, O'Keefe R, Nielsen TO, Taylor EB, Held JM, Hawkins W, Van Tine BA. Brashears CB, et al. Clin Cancer Res. 2022 Aug 15;28(16):3573-3589. doi: 10.1158/1078-0432.CCR-22-0470. Clin Cancer Res. 2022. PMID: 35421237 Free PMC article.
Metabolic compensation activates pro-survival mTORC1 signaling upon 3-phosphoglycerate dehydrogenase inhibition in osteosarcoma.
Rathore R, Caldwell KE, Schutt C, Brashears CB, Prudner BC, Ehrhardt WR, Leung CH, Lin H, Daw NC, Beird HC, Giles A, Wang WL, Lazar AJ, Chrisinger JSA, Livingston JA, Van Tine BA. Rathore R, et al. Among authors: brashears cb. Cell Rep. 2021 Jan 26;34(4):108678. doi: 10.1016/j.celrep.2020.108678. Cell Rep. 2021. PMID: 33503424 Free PMC article.
Arginine Deprivation Inhibits the Warburg Effect and Upregulates Glutamine Anaplerosis and Serine Biosynthesis in ASS1-Deficient Cancers.
Kremer JC, Prudner BC, Lange SES, Bean GR, Schultze MB, Brashears CB, Radyk MD, Redlich N, Tzeng SC, Kami K, Shelton L, Li A, Morgan Z, Bomalaski JS, Tsukamoto T, McConathy J, Michel LS, Held JM, Van Tine BA. Kremer JC, et al. Cell Rep. 2017 Jan 24;18(4):991-1004. doi: 10.1016/j.celrep.2016.12.077. Cell Rep. 2017. PMID: 28122247 Free PMC article.