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Oncostatin M expression induced by bacterial triggers drives airway inflammatory and mucus secretion in severe asthma.
Headland SE, Dengler HS, Xu D, Teng G, Everett C, Ratsimandresy RA, Yan D, Kang J, Ganeshan K, Nazarova EV, Gierke S, Wedeles CJ, Guidi R, DePianto DJ, Morshead KB, Huynh A, Mills J, Flanagan S, Hambro S, Nunez V, Klementowicz JE, Shi Y, Wang J, Bevers J 3rd, Ramirez-Carrozzi V, Pappu R, Abbas A, Vander Heiden J, Choy DF, Yadav R, Modrusan Z, Panettieri RA Jr, Koziol-White C, Jester WF Jr, Jenkins BJ, Cao Y, Clarke C, Austin C, Lafkas D, Xu M, Wolters PJ, Arron JR, West NR, Wilson MS. Headland SE, et al. Among authors: hambro s. Sci Transl Med. 2022 Jan 12;14(627):eabf8188. doi: 10.1126/scitranslmed.abf8188. Epub 2022 Jan 12. Sci Transl Med. 2022. PMID: 35020406
ZBP1 and TRIF trigger lethal necroptosis in mice lacking caspase-8 and TNFR1.
Solon M, Ge N, Hambro S, Haller S, Jiang J, Baca M, Preston J, Maltzman A, Wickliffe KE, Liang Y, Reja R, Nickles D, Newton K, Webster JD. Solon M, et al. Among authors: hambro s. Cell Death Differ. 2024 May;31(5):672-682. doi: 10.1038/s41418-024-01286-6. Epub 2024 Mar 28. Cell Death Differ. 2024. PMID: 38548850 Free PMC article.
Steroid-induced fibroblast growth factors drive an epithelial-mesenchymal inflammatory axis in severe asthma.
Guidi R, Xu D, Choy DF, Ramalingam TR, Lee WP, Modrusan Z, Liang Y, Marsters S, Ashkenazi A, Huynh A, Mills J, Flanagan S, Hambro S, Nunez V, Leong L, Cook A, Tran TH, Austin CD, Cao Y, Clarke C, Panettieri RA Jr, Koziol-White C, Jester WF Jr, Wang F, Wilson MS. Guidi R, et al. Among authors: hambro s. Sci Transl Med. 2022 Apr 20;14(641):eabl8146. doi: 10.1126/scitranslmed.abl8146. Epub 2022 Apr 20. Sci Transl Med. 2022. PMID: 35442706 Free PMC article.
Inhibition of miR-99a-5p prevents allergen-driven airway exacerbations without compromising type-2 memory responses in the intestine following helminth infection.
Entwistle L, Aegerter H, Czieso S, Amaniti E, Guidi R, Sesay A, Nikolov N, Chakravaty P, Huynh A, Mills J, Flanagan S, Hambro S, Nunez V, Cao Y, Clarke C, Martzall A, Leong L, Wilson D, Austin C, Wilson M. Entwistle L, et al. Among authors: hambro s. Mucosal Immunol. 2021 Jul;14(4):912-922. doi: 10.1038/s41385-021-00401-x. Epub 2021 Apr 12. Mucosal Immunol. 2021. PMID: 33846533 Free PMC article.