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vPIF-1 is an insulin-like antiferroptotic viral peptide.
Belavgeni A, Maremonti F, Tonnus W, Stadtmüller M, Gavali S, Mallais M, Flade K, Brucker A, Becker JN, Beer K, Tmava M, Stumpf J, Gembardt F, Hugo C, Giacca M, Hale BG, Perakakis N, Sha W, Pratt DA, Schally AV, Bornstein SR, Linkermann A. Belavgeni A, et al. Among authors: flade k. Proc Natl Acad Sci U S A. 2023 May 23;120(21):e2300320120. doi: 10.1073/pnas.2300320120. Epub 2023 May 15. Proc Natl Acad Sci U S A. 2023. PMID: 37186845 Free PMC article.
Treatment with siRNAs is commonly associated with GPX4 up-regulation and target knockdown-independent sensitization to ferroptosis.
von Mässenhausen A, Schlecht MN, Beer K, Maremonti F, Tonnus W, Belavgeni A, Gavali S, Flade K, Riley JS, Zamora Gonzalez N, Brucker A, Becker JN, Tmava M, Meyer C, Peitzsch M, Hugo C, Gembardt F, Angeli JPF, Bornstein SR, Tait SWG, Linkermann A. von Mässenhausen A, et al. Among authors: flade k. Sci Adv. 2024 Mar 15;10(11):eadk7329. doi: 10.1126/sciadv.adk7329. Epub 2024 Mar 15. Sci Adv. 2024. PMID: 38489367 Free PMC article.
Genome Replication Is Associated With Release of Immunogenic DNA Waste.
Schubert N, Schumann T, Daum E, Flade K, Ge Y, Hagedorn L, Edelmann W, Müller L, Schmitz M, Kuut G, Hornung V, Behrendt R, Roers A. Schubert N, et al. Among authors: flade k. Front Immunol. 2022 May 11;13:880413. doi: 10.3389/fimmu.2022.880413. eCollection 2022. Front Immunol. 2022. PMID: 35634291 Free PMC article.