Lin28b controls a neonatal to adult switch in B cell positive selection.
Vanhee S, Åkerstrand H, Kristiansen TA, Datta S, Montano G, Vergani S, Lang S, Ungerbäck J, Doyle A, Olsson K, Beneventi G, Jensen CT, Bellodi C, Soneji S, Sigvardsson M, Gyllenbäck EJ, Yuan J.
Vanhee S, et al. Among authors: bellodi c.
Sci Immunol. 2019 Sep 27;4(39):eaax4453. doi: 10.1126/sciimmunol.aax4453.
Sci Immunol. 2019.
PMID: 31562190
We show that the heterochronic RNA binding protein Lin28b potentiates a neonatal mode of B cell selection characterized by enhanced overall positive selection in general and the developmental progression of CD5(+) immature B cells in particular. Lin28b achieves this by amplifying …
We show that the heterochronic RNA binding protein Lin28b potentiates a neonatal mode of B cell selection characterized by enhanced overall …