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Page 1
mRNA-lipid nanoparticle COVID-19 vaccines: Structure and stability.
Schoenmaker L, Witzigmann D, Kulkarni JA, Verbeke R, Kersten G, Jiskoot W, Crommelin DJA. Schoenmaker L, et al. Among authors: witzigmann d. Int J Pharm. 2021 May 15;601:120586. doi: 10.1016/j.ijpharm.2021.120586. Epub 2021 Apr 9. Int J Pharm. 2021. PMID: 33839230 Free PMC article. Review.
The current landscape of nucleic acid therapeutics.
Kulkarni JA, Witzigmann D, Thomson SB, Chen S, Leavitt BR, Cullis PR, van der Meel R. Kulkarni JA, et al. Among authors: witzigmann d. Nat Nanotechnol. 2021 Jun;16(6):630-643. doi: 10.1038/s41565-021-00898-0. Epub 2021 May 31. Nat Nanotechnol. 2021. PMID: 34059811 Review.
Spray drying siRNA-lipid nanoparticles for dry powder pulmonary delivery.
Zimmermann CM, Baldassi D, Chan K, Adams NBP, Neumann A, Porras-Gonzalez DL, Wei X, Kneidinger N, Stoleriu MG, Burgstaller G, Witzigmann D, Luciani P, Merkel OM. Zimmermann CM, et al. Among authors: witzigmann d. J Control Release. 2022 Nov;351:137-150. doi: 10.1016/j.jconrel.2022.09.021. Epub 2022 Sep 22. J Control Release. 2022. PMID: 36126785 Free PMC article.
Author Correction: The current landscape of nucleic acid therapeutics.
Kulkarni JA, Witzigmann D, Thomson SB, Chen S, Leavitt BR, Cullis PR, van der Meel R. Kulkarni JA, et al. Among authors: witzigmann d. Nat Nanotechnol. 2021 Jul;16(7):841. doi: 10.1038/s41565-021-00937-w. Nat Nanotechnol. 2021. PMID: 34194013 No abstract available.
Hepatocyte-targeted delivery of imiquimod reduces hepatitis B virus surface antigen.
Al Fayez N, Rouhollahi E, Ong CY, Wu J, Nguyen A, Böttger R, Cullis PR, Witzigmann D, Li SD. Al Fayez N, et al. Among authors: witzigmann d. J Control Release. 2022 Oct;350:630-641. doi: 10.1016/j.jconrel.2022.08.058. Epub 2022 Sep 7. J Control Release. 2022. PMID: 36058352
PFSUVs provided >95% encapsulation efficiency for IMQ at a drug-to-lipid ratio (D/L) of 1/20 (w/w) and displayed stable drug retention in the presence of serum. DSPG-IMQ showed 79% encapsulation of IMQ at 1/20 (D/L) and exhibited 30% burst release when incubated …
PFSUVs provided >95% encapsulation efficiency for IMQ at a drug-to-lipid ratio (D/L) of 1/20 (w/w) and displayed stable drug reten …
In vivo adenine base editing of PCSK9 in macaques reduces LDL cholesterol levels.
Rothgangl T, Dennis MK, Lin PJC, Oka R, Witzigmann D, Villiger L, Qi W, Hruzova M, Kissling L, Lenggenhager D, Borrelli C, Egli S, Frey N, Bakker N, Walker JA 2nd, Kadina AP, Victorov DV, Pacesa M, Kreutzer S, Kontarakis Z, Moor A, Jinek M, Weissman D, Stoffel M, van Boxtel R, Holden K, Pardi N, Thöny B, Häberle J, Tam YK, Semple SC, Schwank G. Rothgangl T, et al. Among authors: witzigmann d. Nat Biotechnol. 2021 Aug;39(8):949-957. doi: 10.1038/s41587-021-00933-4. Epub 2021 May 19. Nat Biotechnol. 2021. PMID: 34012094 Free PMC article.
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