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Targeting the MR1-MAIT cell axis improves vaccine efficacy and affords protection against viral pathogens.
Rashu R, Ninkov M, Wardell CM, Benoit JM, Wang NI, Meilleur CE, D'Agostino MR, Zhang A, Feng E, Saeedian N, Bell GI, Vahedi F, Hess DA, Barr SD, Troyer RM, Kang CY, Ashkar AA, Miller MS, Haeryfar SMM. Rashu R, et al. Among authors: wardell cm. PLoS Pathog. 2023 Jun 29;19(6):e1011485. doi: 10.1371/journal.ppat.1011485. eCollection 2023 Jun. PLoS Pathog. 2023. PMID: 37384813 Free PMC article.
mRNA vaccines take on immune tolerance.
Wardell CM, Levings MK. Wardell CM, et al. Nat Biotechnol. 2021 Apr;39(4):419-421. doi: 10.1038/s41587-021-00880-0. Nat Biotechnol. 2021. PMID: 33785909 No abstract available.
Insulin B peptide-MHC class II-specific chimeric antigen receptor-Tregs prevent autoimmune diabetes.
Spanier JA, Fung V, Wardell CM, Alkhatib MH, Chen Y, Swanson LA, Dwyer AJ, Weno ME, Silva N, Mitchell JS, Orban PC, Mojibian M, Verchere CB, Fife BT, Levings MK. Spanier JA, et al. Among authors: wardell cm. bioRxiv [Preprint]. 2023 Feb 24:2023.02.23.529737. doi: 10.1101/2023.02.23.529737. bioRxiv. 2023. PMID: 36865264 Free PMC article. Updated. Preprint.
PTEN is required for human Treg suppression of costimulation in vitro.
Lam AJ, Haque M, Ward-Hartstonge KA, Uday P, Wardell CM, Gillies JK, Speck M, Mojibian M, Klein Geltink RI, Levings MK. Lam AJ, et al. Among authors: wardell cm. Eur J Immunol. 2022 Sep;52(9):1482-1497. doi: 10.1002/eji.202249888. Epub 2022 Jul 25. Eur J Immunol. 2022. PMID: 35746855 Free article.
Prevention of vascular-allograft rejection by protecting the endothelial glycocalyx with immunosuppressive polymers.
Siren EMJ, Luo HD, Tam F, Montgomery A, Enns W, Moon H, Sim L, Rey K, Guan Q, Wang JJ, Wardell CM, Monajemi M, Mojibian M, Levings MK, Zhang ZJ, Du C, Withers SG, Choy JC, Kizhakkedathu JN. Siren EMJ, et al. Among authors: wardell cm. Nat Biomed Eng. 2021 Oct;5(10):1202-1216. doi: 10.1038/s41551-021-00777-y. Epub 2021 Aug 9. Nat Biomed Eng. 2021. PMID: 34373602
Longitudinal analysis of mucosa-associated invariant T cells in sepsis reveals their early numerical decline with prognostic implications and a progressive loss of antimicrobial functions.
Choi J, Schmerk CL, Mele TS, Rudak PT, Wardell CM, Deng G, Pavri FR, Kim K, Cepinskas G, He W, Haeryfar SM. Choi J, et al. Among authors: wardell cm. Immunol Cell Biol. 2023 Mar;101(3):249-261. doi: 10.1111/imcb.12619. Epub 2023 Feb 1. Immunol Cell Biol. 2023. PMID: 36604951