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Page 1
Lymphangiogenesis requires Ang2/Tie/PI3K signaling for VEGFR3 cell-surface expression.
Korhonen EA, Murtomäki A, Jha SK, Anisimov A, Pink A, Zhang Y, Stritt S, Liaqat I, Stanczuk L, Alderfer L, Sun Z, Kapiainen E, Singh A, Sultan I, Lantta A, Leppänen VM, Eklund L, He Y, Augustin HG, Vaahtomeri K, Saharinen P, Mäkinen T, Alitalo K. Korhonen EA, et al. Among authors: murtomaki a. J Clin Invest. 2022 Aug 1;132(15):e155478. doi: 10.1172/JCI155478. J Clin Invest. 2022. PMID: 35763346 Free PMC article.
Unique functions for Notch4 in murine embryonic lymphangiogenesis.
Muley A, Kim Uh M, Salazar-De Simone G, Swaminathan B, James JM, Murtomaki A, Youn SW, McCarron JD, Kitajewski C, Gnarra Buethe M, Riitano G, Mukouyama YS, Kitajewski J, Shawber CJ. Muley A, et al. Among authors: murtomaki a. Angiogenesis. 2022 May;25(2):205-224. doi: 10.1007/s10456-021-09822-5. Epub 2021 Oct 19. Angiogenesis. 2022. PMID: 34665379 Free PMC article.
Notch signaling functions in lymphatic valve formation.
Murtomaki A, Uh MK, Kitajewski C, Zhao J, Nagasaki T, Shawber CJ, Kitajewski J. Murtomaki A, et al. Development. 2014 Jun;141(12):2446-51. doi: 10.1242/dev.101188. Development. 2014. PMID: 24917500 Free PMC article.
VEGFR-3 controls tip to stalk conversion at vessel fusion sites by reinforcing Notch signalling.
Tammela T, Zarkada G, Nurmi H, Jakobsson L, Heinolainen K, Tvorogov D, Zheng W, Franco CA, Murtomäki A, Aranda E, Miura N, Ylä-Herttuala S, Fruttiger M, Mäkinen T, Eichmann A, Pollard JW, Gerhardt H, Alitalo K. Tammela T, et al. Among authors: murtomaki a. Nat Cell Biol. 2011 Sep 11;13(10):1202-13. doi: 10.1038/ncb2331. Nat Cell Biol. 2011. PMID: 21909098 Free PMC article.
Blocking VEGFR-3 suppresses angiogenic sprouting and vascular network formation.
Tammela T, Zarkada G, Wallgard E, Murtomäki A, Suchting S, Wirzenius M, Waltari M, Hellström M, Schomber T, Peltonen R, Freitas C, Duarte A, Isoniemi H, Laakkonen P, Christofori G, Ylä-Herttuala S, Shibuya M, Pytowski B, Eichmann A, Betsholtz C, Alitalo K. Tammela T, et al. Among authors: murtomaki a. Nature. 2008 Jul 31;454(7204):656-60. doi: 10.1038/nature07083. Epub 2008 Jun 25. Nature. 2008. PMID: 18594512