The SGLT-2 inhibitor empagliflozin improves myocardial strain, reduces cardiac fibrosis and pro-inflammatory cytokines in non-diabetic mice treated with doxorubicin.
Quagliariello V, De Laurentiis M, Rea D, Barbieri A, Monti MG, Carbone A, Paccone A, Altucci L, Conte M, Canale ML, Botti G, Maurea N.
Quagliariello V, et al. Among authors: maurea n.
Cardiovasc Diabetol. 2021 Jul 23;20(1):150. doi: 10.1186/s12933-021-01346-y.
Cardiovasc Diabetol. 2021.
PMID: 34301253
Free PMC article.
Moreover, pro-inflammatory studies were also performed: expression of NLRP3 inflammasome, MyD88 myddosome and p65/NF-kappaB associated to secretion of cytokines involved in cardiotoxicity (Interleukins 1beta, 8, 6). C57Bl/6 mice were untreated (Sham, n = 6) or treated for …
Moreover, pro-inflammatory studies were also performed: expression of NLRP3 inflammasome, MyD88 myddosome and p65/NF-kappaB associated to se …