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Targeted therapy of pyrrolo[2,3-d]pyrimidine antifolates in a syngeneic mouse model of high grade serous ovarian cancer and the impact on the tumor microenvironment.
Wallace-Povirk A, Rubinsak L, Malysa A, Dzinic SH, Ravindra M, Schneider M, Glassbrook J, O'Connor C, Hou Z, Kim S, Back J, Polin L, Morris RT, Gangjee A, Gibson H, Matherly LH. Wallace-Povirk A, et al. Among authors: ravindra m. Sci Rep. 2022 Jul 5;12(1):11346. doi: 10.1038/s41598-022-14788-5. Sci Rep. 2022. PMID: 35790779 Free PMC article.
Discovery of 5-substituted pyrrolo[2,3-d]pyrimidine antifolates as dual-acting inhibitors of glycinamide ribonucleotide formyltransferase and 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase in de novo purine nucleotide biosynthesis: implications of inhibiting 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase to ampk activation and antitumor activity.
Mitchell-Ryan S, Wang Y, Raghavan S, Ravindra MP, Hales E, Orr S, Cherian C, Hou Z, Matherly LH, Gangjee A. Mitchell-Ryan S, et al. Among authors: ravindra mp. J Med Chem. 2013 Dec 27;56(24):10016-10032. doi: 10.1021/jm401328u. Epub 2013 Dec 11. J Med Chem. 2013. PMID: 24256410 Free PMC article.
Tumor Targeting with Novel Pyridyl 6-Substituted Pyrrolo[2,3- d]Pyrimidine Antifolates via Cellular Uptake by Folate Receptor α and the Proton-Coupled Folate Transporter and Inhibition of De Novo Purine Nucleotide Biosynthesis.
Ravindra M, Wallace-Povirk A, Karim MA, Wilson MR, O'Connor C, White K, Kushner J, Polin L, George C, Hou Z, Matherly LH, Gangjee A. Ravindra M, et al. J Med Chem. 2018 Mar 8;61(5):2027-2040. doi: 10.1021/acs.jmedchem.7b01708. Epub 2018 Feb 21. J Med Chem. 2018. PMID: 29425443 Free PMC article.
Fluorine-Substituted Pyrrolo[2,3- d]Pyrimidine Analogues with Tumor Targeting via Cellular Uptake by Folate Receptor α and the Proton-Coupled Folate Transporter and Inhibition of de Novo Purine Nucleotide Biosynthesis.
Ravindra M, Wilson MR, Tong N, O'Connor C, Karim M, Polin L, Wallace-Povirk A, White K, Kushner J, Hou Z, Matherly LH, Gangjee A. Ravindra M, et al. J Med Chem. 2018 May 10;61(9):4228-4248. doi: 10.1021/acs.jmedchem.8b00408. Epub 2018 Apr 27. J Med Chem. 2018. PMID: 29701475 Free PMC article.
Catalytic Isonitrile Insertions and Condensations Initiated by RNC-X Complexation.
Chakrabarty S, Choudhary S, Doshi A, Liu FQ, Mohan R, Ravindra MP, Shah D, Yang X, Fleming FF. Chakrabarty S, et al. Among authors: ravindra mp. Adv Synth Catal. 2014 Jul 7;356(10):2135-2196. doi: 10.1002/adsc.201400017. Epub 2014 Jun 20. Adv Synth Catal. 2014. PMID: 25484847 Free PMC article.