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Showing results for e saw pe[Author]
Your search for E Zaw Pe[Author] retrieved no results
Repolarization of macrophages to improve sorafenib sensitivity for combination cancer therapy.
Huang L, Xu R, Li W, Lv L, Lin C, Yang X, Yao Y, Saw PE, Xu X. Huang L, et al. Among authors: saw pe. Acta Biomater. 2023 May;162:98-109. doi: 10.1016/j.actbio.2023.03.014. Epub 2023 Mar 16. Acta Biomater. 2023. PMID: 36931417
Recent evidences have shown that anticancer drugs with antiangiogenesis effect (e.g., sorafenib) can aggravate the hypoxia microenvironment and promote the infiltration of more tumor-associated macrophages (TAMs) into the tumor tissues. ...STATEMENT OF SIGNIFICANCE: Antica …
Recent evidences have shown that anticancer drugs with antiangiogenesis effect (e.g., sorafenib) can aggravate the hypoxia microenvir …
Role of long non-coding RNAs in cancer: From subcellular localization to nanoparticle-mediated targeted regulation.
Wei C, Xu Y, Shen Q, Li R, Xiao X, Saw PE, Xu X. Wei C, et al. Among authors: saw pe. Mol Ther Nucleic Acids. 2023 Jul 16;33:774-793. doi: 10.1016/j.omtn.2023.07.009. eCollection 2023 Sep 12. Mol Ther Nucleic Acids. 2023. PMID: 37655045 Free PMC article. Review.
More importantly, based on the important roles of lncRNAs in regulating cancer progression (e.g., growth, therapeutic resistance, and metastasis) and the specific ability of nucleic acids (e.g., siRNA, mRNA, and DNA) to regulate the expression of any target genes, m …
More importantly, based on the important roles of lncRNAs in regulating cancer progression (e.g., growth, therapeutic resistance, and …
Concurrent silencing of TBCE and drug delivery to overcome platinum-based resistance in liver cancer.
Li S, Chen S, Dong Z, Song X, Li X, Huang Z, Li H, Huang L, Zhuang G, Lan R, Guo M, Li W, Saw PE, Zhang L. Li S, et al. Among authors: saw pe. Acta Pharm Sin B. 2023 Mar;13(3):967-981. doi: 10.1016/j.apsb.2022.03.003. Epub 2022 Mar 12. Acta Pharm Sin B. 2023. PMID: 36970197 Free PMC article.
Herein, RNAseq analysis revealed that elevated tubulin folding cofactor E (TBCE) expression is associated with platinum-based chemotherapy resistance. ...
Herein, RNAseq analysis revealed that elevated tubulin folding cofactor E (TBCE) expression is associated with platinum-based chemoth …
Fully Natural Lecithin Encapsulated Nano-Resveratrol for Anti-Cancer Therapy.
Liang M, Guo M, Saw PE, Yao Y. Liang M, et al. Among authors: saw pe. Int J Nanomedicine. 2022 May 6;17:2069-2078. doi: 10.2147/IJN.S362418. eCollection 2022. Int J Nanomedicine. 2022. PMID: 35571257 Free PMC article.
INTRODUCTION: Chemotherapeutics are known to have undesirable side effects (i.e. nausea, weight loss, hair loss, weakened immune system, etc.) due to the non-specificity of the drugs. ...
INTRODUCTION: Chemotherapeutics are known to have undesirable side effects (i.e. nausea, weight loss, hair loss, weakened immune syst …
Two-Dimensional Antimonene-Based Photonic Nanomedicine for Cancer Theranostics.
Tao W, Ji X, Zhu X, Li L, Wang J, Zhang Y, Saw PE, Li W, Kong N, Islam MA, Gan T, Zeng X, Zhang H, Mahmoudi M, Tearney GJ, Farokhzad OC. Tao W, et al. Among authors: saw pe. Adv Mater. 2018 Sep;30(38):e1802061. doi: 10.1002/adma.201802061. Epub 2018 Jul 24. Adv Mater. 2018. PMID: 30043416 Free PMC article.
The platform's multiple advantages include: i) excellent photothermal properties, ii) high drug-loading capacity, iii) spatiotemporally controlled drug release triggered by near-infrared (NIR) light and moderate acidic pH, iv) superior accumulation at tumor sites, v) deep tumor p …
The platform's multiple advantages include: i) excellent photothermal properties, ii) high drug-loading capacity, iii) spatiotemporally cont …
Nanoparticle-Mediated Inhibition of Mitochondrial Glutaminolysis to Amplify Oxidative Stress for Combination Cancer Therapy.
Xu L, Xu R, Saw PE, Wu J, Cheng SX, Xu X. Xu L, et al. Among authors: saw pe. Nano Lett. 2021 Sep 22;21(18):7569-7578. doi: 10.1021/acs.nanolett.1c02073. Epub 2021 Sep 2. Nano Lett. 2021. PMID: 34472343
However, an abnormal tumor metabolism, especially the mitochondrial glutaminolysis, could promote tumor cells to generate high levels of antioxidants (e.g., glutathione) to evade ROS-induced damage. Here, we developed a tumor-targeted nanoparticle (NP) platform for effecti …
However, an abnormal tumor metabolism, especially the mitochondrial glutaminolysis, could promote tumor cells to generate high levels of ant …
Multifunctional Envelope-Type siRNA Delivery Nanoparticle Platform for Prostate Cancer Therapy.
Xu X, Wu J, Liu Y, Saw PE, Tao W, Yu M, Zope H, Si M, Victorious A, Rasmussen J, Ayyash D, Farokhzad OC, Shi J. Xu X, et al. Among authors: saw pe. ACS Nano. 2017 Mar 28;11(3):2618-2627. doi: 10.1021/acsnano.6b07195. Epub 2017 Mar 3. ACS Nano. 2017. PMID: 28240870 Free PMC article.
One key challenge for the clinical applications of RNAi is the safe and effective delivery of RNAi agents such as small interfering RNA (siRNA) to a particular nonliver diseased tissue (e.g., tumor) and cell type with sufficient cytosolic transport. ...
One key challenge for the clinical applications of RNAi is the safe and effective delivery of RNAi agents such as small interfering RNA (siR …
Long-Circulating Theranostic 2D Metal-Organic Frameworks with Concurrent O2 Self-Supplying and GSH Depletion Characteristic for Enhanced Cancer Chemodynamic Therapy.
Xu R, Saw PE, Xu L. Xu R, et al. Among authors: saw pe. Small Methods. 2022 Jun;6(6):e2200178. doi: 10.1002/smtd.202200178. Epub 2022 Apr 24. Small Methods. 2022. PMID: 35466561
Moreover, rapid depletion of ROS by the high level of antioxidants (e.g., glutathione) in cancer cells severely limits the therapeutic effects of cancer CDT. ...
Moreover, rapid depletion of ROS by the high level of antioxidants (e.g., glutathione) in cancer cells severely limits the therapeuti …
Hyper-cell-permeable micelles as a drug delivery carrier for effective cancer therapy.
Saw PE, Yu M, Choi M, Lee E, Jon S, Farokhzad OC. Saw PE, et al. Biomaterials. 2017 Apr;123:118-126. doi: 10.1016/j.biomaterials.2017.01.040. Epub 2017 Jan 31. Biomaterials. 2017. PMID: 28167390
Herein, we describe a simple modification of bicellar formulation in which the addition of a PEGylated phospholipid produced a dramatic physicochemical change in morphology, i.e., the disc-shaped bicelle became a uniformly distributed ultra-small (12 nm) spherical micelle. …
Herein, we describe a simple modification of bicellar formulation in which the addition of a PEGylated phospholipid produced a dramatic phys …
Nanoparticles targeting extra domain B of fibronectin-specific to the atherosclerotic lesion types III, IV, and V-enhance plaque detection and cargo delivery.
Yu M, Ortega CA, Si K, Molinaro R, Schoen FJ, Leitao RFC, Xu X, Mahmoudi M, Ahn S, Liu J, Saw PE, Lee IH, Brayner MMB, Lotfi A, Shi J, Libby P, Jon S, Farokhzad OC. Yu M, et al. Among authors: saw pe. Theranostics. 2018 Nov 15;8(21):6008-6024. doi: 10.7150/thno.24365. eCollection 2018. Theranostics. 2018. PMID: 30613278 Free PMC article.
MRI visualized APT(FN-EDB)-[Gd]NPs administered to atherosclerotic apolipoprotein E-deficient mice in the brachiocephalic arteries. Analysis of the ascending-to-descending thoracic aortas and the aortic roots of the mice permitted quantitation of Gd, FN-EDB, and APT(FN-EDB …
MRI visualized APT(FN-EDB)-[Gd]NPs administered to atherosclerotic apolipoprotein E-deficient mice in the brachiocephalic arteries. A …