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Year Number of Results
1983 2
1984 3
1985 3
1987 1
1989 2
1990 4
1991 3
1992 8
1993 6
1994 1
1995 7
1996 9
1997 6
1998 9
1999 25
2000 12
2001 21
2002 23
2003 37
2004 41
2005 46
2006 68
2007 69
2008 76
2009 75
2010 138
2011 125
2012 156
2013 170
2014 222
2015 285
2016 292
2017 287
2018 390
2019 457
2020 476
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2022 685
2023 708
2024 331

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5,219 results

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Page 1
N6-methyladenosine-dependent regulation of messenger RNA stability.
Wang X, Lu Z, Gomez A, Hon GC, Yue Y, Han D, Fu Y, Parisien M, Dai Q, Jia G, Ren B, Pan T, He C. Wang X, et al. Among authors: jia g. Nature. 2014 Jan 2;505(7481):117-20. doi: 10.1038/nature12730. Epub 2013 Nov 27. Nature. 2014. PMID: 24284625 Free PMC article.
N(6)-methyladenosine (m(6)A) is the most prevalent internal (non-cap) modification present in the messenger RNA of all higher eukaryotes. Although essential to cell viability and development, the exact role of m(6)A modification remains to be determined. The recent …
N(6)-methyladenosine (m(6)A) is the most prevalent internal (non-cap) modification present in the messenger RNA of all higher eukaryo …
Autophagy induction promoted by m(6)A reader YTHDF3 through translation upregulation of FOXO3 mRNA.
Hao W, Dian M, Zhou Y, Zhong Q, Pang W, Li Z, Zhao Y, Ma J, Lin X, Luo R, Li Y, Jia J, Shen H, Huang S, Dai G, Wang J, Sun Y, Xiao D. Hao W, et al. Among authors: jia j. Nat Commun. 2022 Oct 4;13(1):5845. doi: 10.1038/s41467-022-32963-0. Nat Commun. 2022. PMID: 36195598 Free PMC article.
Here, we show that the m(6)A reader YTHDF3 is essential for autophagy induction. m(6)A modification is up-regulated to promote autophagosome formation and lysosomal degradation upon nutrient deficiency. METTL3 depletion leads to a loss of functional m(6)A mod …
Here, we show that the m(6)A reader YTHDF3 is essential for autophagy induction. m(6)A modification is up-regulated to promote …
m(6)A methylation: a process reshaping the tumour immune microenvironment and regulating immune evasion.
Cao X, Geng Q, Fan D, Wang Q, Wang X, Zhang M, Zhao L, Jiao Y, Deng T, Liu H, Zhou J, Jia L, Xiao C. Cao X, et al. Among authors: jia l. Mol Cancer. 2023 Mar 1;22(1):42. doi: 10.1186/s12943-022-01704-8. Mol Cancer. 2023. PMID: 36859310 Free PMC article. Review.
With elaborate functions executed by m(6)A writers, erasers, and readers, m(6)A modulation is involved in myriad physiological and pathological processes. ...Recent evidence has revealed an emerging role of m(6)A modulation in tumour immunoregulation, and div …
With elaborate functions executed by m(6)A writers, erasers, and readers, m(6)A modulation is involved in myriad physiological …
Differential m(6)A, m(6)A(m), and m(1)A Demethylation Mediated by FTO in the Cell Nucleus and Cytoplasm.
Wei J, Liu F, Lu Z, Fei Q, Ai Y, He PC, Shi H, Cui X, Su R, Klungland A, Jia G, Chen J, He C. Wei J, et al. Among authors: jia g. Mol Cell. 2018 Sep 20;71(6):973-985.e5. doi: 10.1016/j.molcel.2018.08.011. Epub 2018 Sep 6. Mol Cell. 2018. PMID: 30197295 Free PMC article.
We find that FTO binds multiple RNA species, including mRNA, snRNA, and tRNA, and can demethylate internal m(6)A and cap m(6)A(m) in mRNA, internal m(6)A in U6 RNA, internal and cap m(6)A(m) in snRNAs, and N(1)-methyladenosine (m(1 …
We find that FTO binds multiple RNA species, including mRNA, snRNA, and tRNA, and can demethylate internal m(6)A and cap m(6)A …
A METTL3-METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation.
Liu J, Yue Y, Han D, Wang X, Fu Y, Zhang L, Jia G, Yu M, Lu Z, Deng X, Dai Q, Chen W, He C. Liu J, et al. Among authors: jia g. Nat Chem Biol. 2014 Feb;10(2):93-5. doi: 10.1038/nchembio.1432. Epub 2013 Dec 6. Nat Chem Biol. 2014. PMID: 24316715 Free PMC article.
N(6)-methyladenosine (m(6)A) is the most prevalent and reversible internal modification in mammalian messenger and noncoding RNAs. We report here that human methyltransferase-like 14 (METTL14) catalyzes m(6)A RNA methylation. Together with METTL3, the only previousl …
N(6)-methyladenosine (m(6)A) is the most prevalent and reversible internal modification in mammalian messenger and noncoding RNAs. We …
Mettl3-/Mettl14-mediated mRNA N6-methyladenosine modulates murine spermatogenesis.
Lin Z, Hsu PJ, Xing X, Fang J, Lu Z, Zou Q, Zhang KJ, Zhang X, Zhou Y, Zhang T, Zhang Y, Song W, Jia G, Yang X, He C, Tong MH. Lin Z, et al. Among authors: jia g. Cell Res. 2017 Oct;27(10):1216-1230. doi: 10.1038/cr.2017.117. Epub 2017 Sep 15. Cell Res. 2017. PMID: 28914256 Free PMC article.
We present comprehensive m(6)A mRNA methylomes of mouse spermatogenic cells from five developmental stages: undifferentiated spermatogonia, type A(1) spermatogonia, preleptotene spermatocytes, pachytene/diplotene spermatocytes, and round spermatids. Germ cell-specific inac …
We present comprehensive m(6)A mRNA methylomes of mouse spermatogenic cells from five developmental stages: undifferentiated spermato …
METTL14 aggravates endothelial inflammation and atherosclerosis by increasing FOXO1 N6-methyladeosine modifications.
Jian D, Wang Y, Jian L, Tang H, Rao L, Chen K, Jia Z, Zhang W, Liu Y, Chen X, Shen X, Gao C, Wang S, Li M. Jian D, et al. Among authors: jia z. Theranostics. 2020 Jul 11;10(20):8939-8956. doi: 10.7150/thno.45178. eCollection 2020. Theranostics. 2020. PMID: 32802173 Free PMC article.
Aims: The N6-methyladenosine (m(6)A) modification plays an important role in various biological processes, but its role in atherosclerosis remains unknown. ...The m(6)A-modified mRNAs were identified by methylated RNA immunoprecipitation (RIP) sequencing and forkhea …
Aims: The N6-methyladenosine (m(6)A) modification plays an important role in various biological processes, but its role in atheroscle …
An Elongation- and Ligation-Based qPCR Amplification Method for the Radiolabeling-Free Detection of Locus-Specific N6 -Methyladenosine Modification.
Xiao Y, Wang Y, Tang Q, Wei L, Zhang X, Jia G. Xiao Y, et al. Among authors: jia g. Angew Chem Int Ed Engl. 2018 Dec 3;57(49):15995-16000. doi: 10.1002/anie.201807942. Epub 2018 Nov 8. Angew Chem Int Ed Engl. 2018. PMID: 30345651
The epitranscriptomic mark N(6) -methyladenosine (m(6) A) is the most abundant RNA modification in eukaryotic mRNA, but various limitations in currently available m(6) A detection methods have precluded routine identification of m(6) A marks at the single-sit …
The epitranscriptomic mark N(6) -methyladenosine (m(6) A) is the most abundant RNA modification in eukaryotic mRNA, but various limit …
Targeting histone deacetylase suppresses tumor growth through eliciting METTL14-modified m(6) A RNA methylation in ocular melanoma.
Zhuang A, Gu X, Ge T, Wang S, Ge S, Chai P, Jia R, Fan X. Zhuang A, et al. Among authors: jia r. Cancer Commun (Lond). 2023 Nov;43(11):1185-1206. doi: 10.1002/cac2.12471. Epub 2023 Jul 19. Cancer Commun (Lond). 2023. PMID: 37466203 Free PMC article.
Howbeit, an in-depth understanding of the crosstalk between histone acetylation and m(6) A RNA modifications remains enigmatic. This study aimed to explore the role of histone acetylation and m(6) A modifications in the regulation of tumorigenesis of ocular melanoma …
Howbeit, an in-depth understanding of the crosstalk between histone acetylation and m(6) A RNA modifications remains enigmatic. This …
m(6)A regulator-based methylation modification patterns characterized by distinct tumor microenvironment immune profiles in colon cancer.
Chong W, Shang L, Liu J, Fang Z, Du F, Wu H, Liu Y, Wang Z, Chen Y, Jia S, Chen L, Li L, Chen H. Chong W, et al. Among authors: jia s. Theranostics. 2021 Jan 1;11(5):2201-2217. doi: 10.7150/thno.52717. eCollection 2021. Theranostics. 2021. PMID: 33500720 Free PMC article.
Methods: In this study, we curated 23 m(6)A regulators and performed consensus molecular subtyping with NMF algorithm to determine m(6)A modification patterns and the m(6)A-related gene signature in colon cancer (CC). ...Based on the m(6)Sig score, whi …
Methods: In this study, we curated 23 m(6)A regulators and performed consensus molecular subtyping with NMF algorithm to determine …
5,219 results