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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1981 3
1984 1
1985 1
1986 2
1987 1
1989 4
1990 3
1991 3
1992 6
1993 6
1994 6
1995 5
1996 10
1997 6
1998 14
1999 22
2000 27
2001 19
2002 39
2003 39
2004 35
2005 70
2006 96
2007 102
2008 105
2009 115
2010 139
2011 166
2012 177
2013 263
2014 425
2015 548
2016 581
2017 668
2018 787
2019 760
2020 915
2021 945
2022 1094
2023 1126
2024 550
2025 1

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8,899 results

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Page 1
R-2HG Exhibits Anti-tumor Activity by Targeting FTO/m(6)A/MYC/CEBPA Signaling.
Su R, Dong L, Li C, Nachtergaele S, Wunderlich M, Qing Y, Deng X, Wang Y, Weng X, Hu C, Yu M, Skibbe J, Dai Q, Zou D, Wu T, Yu K, Weng H, Huang H, Ferchen K, Qin X, Zhang B, Qi J, Sasaki AT, Plas DR, Bradner JE, Wei M, Marcucci G, Jiang X, Mulloy JC, Jin J, He C, Chen J. Su R, et al. Among authors: dai q. Cell. 2018 Jan 11;172(1-2):90-105.e23. doi: 10.1016/j.cell.2017.11.031. Epub 2017 Dec 14. Cell. 2018. PMID: 29249359 Free PMC article.
R-2-hydroxyglutarate (R-2HG), produced at high levels by mutant isocitrate dehydrogenase 1/2 (IDH1/2) enzymes, was reported as an oncometabolite. ...Ectopically expressed mutant IDH1 and S-2HG recapitulate the effects of R-2HG. High levels of FTO sensitize le …
R-2-hydroxyglutarate (R-2HG), produced at high levels by mutant isocitrate dehydrogenase 1/2 (IDH1/2) enzymes, was reported as …
Targeted therapy and immunotherapy for T cell acute lymphoblastic leukemia/lymphoma.
Huang YH, Wan CL, Dai HP, Xue SL. Huang YH, et al. Among authors: dai hp. Ann Hematol. 2023 Aug;102(8):2001-2013. doi: 10.1007/s00277-023-05286-3. Epub 2023 May 25. Ann Hematol. 2023. PMID: 37227492 Review.
Despite significant improvements in survival of T-ALL/LBL over the past decades, treatment of relapsed and refractory T-ALL (R/R T-ALL/LBL) remains extremely challenging. The prognosis of R/R T-ALL/LBL patients who are intolerant to intensive chemother …
Despite significant improvements in survival of T-ALL/LBL over the past decades, treatment of relapsed and refractory T-ALL (R/R …
Tumor-associated macrophages are shaped by intratumoral high potassium via Kir2.1.
Chen S, Cui W, Chi Z, Xiao Q, Hu T, Ye Q, Zhu K, Yu W, Wang Z, Yu C, Pan X, Dai S, Yang Q, Jin J, Zhang J, Li M, Yang D, Yu Q, Wang Q, Yu X, Yang W, Zhang X, Qian J, Ding K, Wang D. Chen S, et al. Among authors: dai s. Cell Metab. 2022 Nov 1;34(11):1843-1859.e11. doi: 10.1016/j.cmet.2022.08.016. Epub 2022 Sep 13. Cell Metab. 2022. PMID: 36103895 Free article.
Heart-gut microbiota communication determines the severity of cardiac injury after myocardial ischaemia/reperfusion.
Zhao J, Zhang Q, Cheng W, Dai Q, Wei Z, Guo M, Chen F, Qiao S, Hu J, Wang J, Chen H, Bao X, Mu D, Sun X, Xu B, Xie J. Zhao J, et al. Among authors: dai q. Cardiovasc Res. 2023 Jun 13;119(6):1390-1402. doi: 10.1093/cvr/cvad023. Cardiovasc Res. 2023. PMID: 36715640 Free PMC article.
Then, we used a mouse model to determine the effects of myocardial I/R injury on gut microbiota dysbiosis and translocation. Blooming of Proteobacteria was identified as a hallmark of post-I/R dysbiosis, which was associated with gut bacteria translocation. Abrogati …
Then, we used a mouse model to determine the effects of myocardial I/R injury on gut microbiota dysbiosis and translocation. Blooming …
Lateral septum adenosine A2A receptors control stress-induced depressive-like behaviors via signaling to the hypothalamus and habenula.
Wang M, Li P, Li Z, da Silva BS, Zheng W, Xiang Z, He Y, Xu T, Cordeiro C, Deng L, Dai Y, Ye M, Lin Z, Zhou J, Zhou X, Ye F, Cunha RA, Chen J, Guo W. Wang M, et al. Among authors: dai y. Nat Commun. 2023 Apr 5;14(1):1880. doi: 10.1038/s41467-023-37601-x. Nat Commun. 2023. PMID: 37019936 Free PMC article.
Activation of A(2A)R in the LS augmented the spiking frequency of A(2A)R-positive neurons leading to a decreased activation of surrounding neurons and the bi-directional manipulation of LS-A(2A)R activity demonstrated that LS-A(2A)Rs are necessary and suffici …
Activation of A(2A)R in the LS augmented the spiking frequency of A(2A)R-positive neurons leading to a decreased activation of …
Histamine H2 receptor deficit in glutamatergic neurons contributes to the pathogenesis of schizophrenia.
Ma Q, Jiang L, Chen H, An D, Ping Y, Wang Y, Dai H, Zhang X, Wang Y, Chen Z, Hu W. Ma Q, et al. Among authors: dai h. Proc Natl Acad Sci U S A. 2023 Feb 28;120(9):e2207003120. doi: 10.1073/pnas.2207003120. Epub 2023 Feb 22. Proc Natl Acad Sci U S A. 2023. PMID: 36812204 Free PMC article.
In addition, either H(2)R overexpression in glutamatergic neurons or H(2)R agonism in the mPFC counteracted schizophrenia-like phenotypes in an MK-801-induced mouse model of schizophrenia. Taken together, our results suggest that deficit of H(2)R in mPFC glut …
In addition, either H(2)R overexpression in glutamatergic neurons or H(2)R agonism in the mPFC counteracted schizophrenia-like …
Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities.
Jia N, Wang J, Shi W, Du L, Sun Y, Zhan W, Jiang JF, Wang Q, Zhang B, Ji P, Bell-Sakyi L, Cui XM, Yuan TT, Jiang BG, Yang WF, Lam TT, Chang QC, Ding SJ, Wang XJ, Zhu JG, Ruan XD, Zhao L, Wei JT, Ye RZ, Que TC, Du CH, Zhou YH, Cheng JX, Dai PF, Guo WB, Han XH, Huang EJ, Li LF, Wei W, Gao YC, Liu JZ, Shao HZ, Wang X, Wang CC, Yang TC, Huo QB, Li W, Chen HY, Chen SE, Zhou LG, Ni XB, Tian JH, Sheng Y, Liu T, Pan YS, Xia LY, Li J; Tick Genome and Microbiome Consortium (TIGMIC); Zhao F, Cao WC. Jia N, et al. Among authors: dai pf. Cell. 2020 Sep 3;182(5):1328-1340.e13. doi: 10.1016/j.cell.2020.07.023. Epub 2020 Aug 18. Cell. 2020. PMID: 32814014 Free article.
Astragaloside IV Alleviates Cerebral Ischemia-Reperfusion Injury through NLRP3 Inflammasome-Mediated Pyroptosis Inhibition via Activating Nrf2.
Xiao L, Dai Z, Tang W, Liu C, Tang B. Xiao L, et al. Among authors: dai z. Oxid Med Cell Longev. 2021 Dec 30;2021:9925561. doi: 10.1155/2021/9925561. eCollection 2021. Oxid Med Cell Longev. 2021. PMID: 35003524 Free PMC article.
CIRI was induced by middle cerebral artery occlusion-reperfusion (MCAO/R) in Sprague Dawley rats and modeled by oxygen and glucose deprivation/reoxygenation (OGD/R) in SH-SY5Y cells. ...In turn, MCAO/R and OGD/R enhanced the protein levels of NLRP3, Ca …
CIRI was induced by middle cerebral artery occlusion-reperfusion (MCAO/R) in Sprague Dawley rats and modeled by oxygen and glucose de …
Efficacy and safety of a novel anti-HER2 therapeutic antibody RC48 in patients with HER2-overexpressing, locally advanced or metastatic gastric or gastroesophageal junction cancer: a single-arm phase II study.
Peng Z, Liu T, Wei J, Wang A, He Y, Yang L, Zhang X, Fan N, Luo S, Li Z, Gu K, Lu J, Xu J, Fan Q, Xu R, Zhang L, Li E, Sun Y, Yu G, Bai C, Liu Y, Zeng J, Ying J, Liang X, Xu N, Gao C, Shu Y, Ma D, Dai G, Li S, Deng T, Cui Y, Fang J, Ba Y, Shen L. Peng Z, et al. Among authors: dai g. Cancer Commun (Lond). 2021 Nov;41(11):1173-1182. doi: 10.1002/cac2.12214. Epub 2021 Oct 19. Cancer Commun (Lond). 2021. PMID: 34665942 Free PMC article. Clinical Trial.
Venetoclax Combined with Azacitidine and Homoharringtonine in Relapsed/Refractory AML: A Multicenter, Phase 2 Trial.
Jin H, Zhang Y, Yu S, Du X, Xu N, Shao R, Lin D, Chen Y, Xiao J, Sun Z, Deng L, Liang X, Zhang H, Guo Z, Dai M, Shi P, Huang F, Fan Z, Yin Z, Xuan L, Lin R, Jiang X, Yu G, Liu Q. Jin H, et al. Among authors: dai m. J Hematol Oncol. 2023 Apr 29;16(1):42. doi: 10.1186/s13045-023-01437-1. J Hematol Oncol. 2023. PMID: 37120593 Free PMC article. Clinical Trial.
BACKGROUND: Relapsed or refractory acute myeloid leukemia (R/R AML) has a dismal prognosis. The aim of this study was to investigate the activity and tolerability of venetoclax combined with azacitidine plus homoharringtonine (VAH) regimen for R/R AML. …
BACKGROUND: Relapsed or refractory acute myeloid leukemia (R/R AML) has a dismal prognosis. The aim of this study was to inves …
8,899 results