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Inflammatory exposure drives long-lived impairment of hematopoietic stem cell self-renewal activity and accelerated aging.
Bogeska R, Mikecin AM, Kaschutnig P, Fawaz M, Büchler-Schäff M, Le D, Ganuza M, Vollmer A, Paffenholz SV, Asada N, Rodriguez-Correa E, Frauhammer F, Buettner F, Ball M, Knoch J, Stäble S, Walter D, Petri A, Carreño-Gonzalez MJ, Wagner V, Brors B, Haas S, Lipka DB, Essers MAG, Weru V, Holland-Letz T, Mallm JP, Rippe K, Krämer S, Schlesner M, McKinney Freeman S, Florian MC, King KY, Frenette PS, Rieger MA, Milsom MD. Bogeska R, et al. Among authors: rodriguez correa e. Cell Stem Cell. 2022 Aug 4;29(8):1273-1284.e8. doi: 10.1016/j.stem.2022.06.012. Epub 2022 Jul 19. Cell Stem Cell. 2022. PMID: 35858618 Free PMC article.
Usp22 is an intracellular regulator of systemic emergency hematopoiesis.
Dietlein N, Wang X, Metz J, Disson O, Shang F, Beyersdörffer C, Rodríguez Correa E, Lipka DB, Begus-Nahrmann Y, Kosinsky RL, Johnsen SA, Lecuit M, Höfer T, Rodewald HR. Dietlein N, et al. Among authors: rodriguez correa e. Sci Immunol. 2022 Dec 16;7(78):eabq2061. doi: 10.1126/sciimmunol.abq2061. Epub 2022 Dec 9. Sci Immunol. 2022. PMID: 36490327 Free article.
Tau in the brain interstitial fluid is fragmented and seeding-competent.
Barini E, Plotzky G, Mordashova Y, Hoppe J, Rodriguez-Correa E, Julier S, LePrieult F, Mairhofer I, Mezler M, Biesinger S, Cik M, Meinhardt MW, Ercan-Herbst E, Ehrnhoefer DE, Striebinger A, Bodie K, Klein C, Gasparini L, Schlegel K. Barini E, et al. Among authors: rodriguez correa e. Neurobiol Aging. 2022 Jan;109:64-77. doi: 10.1016/j.neurobiolaging.2021.09.013. Epub 2021 Sep 17. Neurobiol Aging. 2022. PMID: 34655982 Free article.