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Page 1
The ClpP activator ONC-212 (TR-31) inhibits BCL2 and B-cell receptor signaling in CLL.
EJHaem. 2021 Jan 14;2(1):81-93. doi: 10.1002/jha2.160. eCollection 2021 Feb.
EJHaem. 2021.
PMID: 35846080
Free PMC article.
Characterization of TR-107, a novel chemical activator of the human mitochondrial protease ClpP.
Fennell EMJ, Aponte-Collazo LJ, Wynn JD, Drizyte-Miller K, Leung E, Greer YE, Graves PR, Iwanowicz AA, Ashamalla H, Holmuhamedov E, Lang H, Karanewsky DS, Der CJ, Houry WA, Lipkowitz S, Iwanowicz EJ, Graves LM.
Fennell EMJ, et al. Among authors: lang h.
Pharmacol Res Perspect. 2022 Aug;10(4):e00993. doi: 10.1002/prp2.993.
Pharmacol Res Perspect. 2022.
PMID: 35929764
Free PMC article.
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Potent ClpP agonists with anticancer properties bind with improved structural complementarity and alter the mitochondrial N-terminome.
Mabanglo MF, Wong KS, Barghash MM, Leung E, Chuang SHW, Ardalan A, Majaesic EM, Wong CJ, Zhang S, Lang H, Karanewsky DS, Iwanowicz AA, Graves LM, Iwanowicz EJ, Gingras AC, Houry WA.
Mabanglo MF, et al. Among authors: lang h.
Structure. 2023 Feb 2;31(2):185-200.e10. doi: 10.1016/j.str.2022.12.002. Epub 2022 Dec 30.
Structure. 2023.
PMID: 36586405
Free PMC article.
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The CIpP activator, TR-57, is highly effective as a single agent and in combination with venetoclax against CLL cells in vitro.
Fatima N, Shen Y, Crassini K, Burling O, Thurgood L, Iwanowicz EJ, Lang H, Karanewsky DS, Christopherson RI, Mulligan SP, Best OG.
Fatima N, et al. Among authors: lang h.
Leuk Lymphoma. 2024 May;65(5):585-597. doi: 10.1080/10428194.2023.2300055. Epub 2024 Jan 16.
Leuk Lymphoma. 2024.
PMID: 38227293
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Novel-smoothened inhibitors for therapeutic targeting of naïve and drug-resistant hedgehog pathway-driven cancers.
Li QR, Zhao H, Zhang XS, Lang H, Yu K.
Li QR, et al. Among authors: lang h.
Acta Pharmacol Sin. 2019 Feb;40(2):257-267. doi: 10.1038/s41401-018-0019-5. Epub 2018 May 18.
Acta Pharmacol Sin. 2019.
PMID: 29777201
Free PMC article.
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Identification and SAR of selective inducible nitric oxide synthase (iNOS) dimerization inhibitors.
Gahman TC, Herbert MR, Lang H, Thayer A, Symons KT, Nguyen PM, Massari ME, Dozier S, Zhang Y, Sablad M, Rao TS, Noble SA, Shiau AK, Hassig CA.
Gahman TC, et al. Among authors: lang h.
Bioorg Med Chem Lett. 2011 Nov 15;21(22):6888-94. doi: 10.1016/j.bmcl.2011.08.112. Epub 2011 Sep 8.
Bioorg Med Chem Lett. 2011.
PMID: 21986586
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Systems-based design of bi-ligand inhibitors of oxidoreductases: filling the chemical proteomic toolbox.
Sem DS, Bertolaet B, Baker B, Chang E, Costache AD, Coutts S, Dong Q, Hansen M, Hong V, Huang X, Jack RM, Kho R, Lang H, Ma CT, Meininger D, Pellecchia M, Pierre F, Villar H, Yu L.
Sem DS, et al. Among authors: lang h.
Chem Biol. 2004 Feb;11(2):185-94. doi: 10.1016/j.chembiol.2004.02.012.
Chem Biol. 2004.
PMID: 15123280
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