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d koellinger[Author]
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Proteolytic Degradation of reduced Human Beta Defensin 1 generates a Novel Antibiotic Octapeptide.
Sci Rep. 2019 Mar 6;9(1):3640. doi: 10.1038/s41598-019-40216-2.
Sci Rep. 2019.
PMID: 30842543
Free PMC article.
We modified the octapeptide by stabilizing its termini and by using non-natural D-amino acids. The native and modified peptide variants showed antibiotic activity against pathogenic as well as antibiotic-resistant microorganisms, including E. coli, P. aeruginosa and C. alb …
We modified the octapeptide by stabilizing its termini and by using non-natural D-amino acids. The native and modified peptide varian …
Paneth cell α-defensins HD-5 and HD-6 display differential degradation into active antimicrobial fragments.
Ehmann D, Wendler J, Koeninger L, Larsen IS, Klag T, Berger J, Marette A, Schaller M, Stange EF, Malek NP, Jensen BAH, Wehkamp J.
Ehmann D, et al. Among authors: koeninger l.
Proc Natl Acad Sci U S A. 2019 Feb 26;116(9):3746-3751. doi: 10.1073/pnas.1817376116. Epub 2019 Feb 11.
Proc Natl Acad Sci U S A. 2019.
PMID: 30808760
Free PMC article.
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