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Page 1
Efficient Ligand Discovery Using Sulfur(VI) Fluoride Reactive Fragments.
ACS Chem Biol. 2023 Sep 15;18(9):1926-1937. doi: 10.1021/acschembio.3c00034. Epub 2023 Apr 21.
ACS Chem Biol. 2023.
PMID: 37084287
Free PMC article.
Characterisation of utrophin modulator SMT C1100 as a non-competitive inhibitor of firefly luciferase.
Wilkinson IVL, Reynolds JK, Galan SRG, Vuorinen A, Sills AJ, Pires E, Wynne GM, Wilson FX, Russell AJ.
Wilkinson IVL, et al. Among authors: vuorinen a.
Bioorg Chem. 2020 Jan;94:103395. doi: 10.1016/j.bioorg.2019.103395. Epub 2019 Oct 28.
Bioorg Chem. 2020.
PMID: 31733898
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A tubulin binding molecule drives differentiation of acute myeloid leukemia cells.
Jackson TR, Vuorinen A, Josa-Culleré L, Madden KS, Conole D, Cogswell TJ, Wilkinson IVL, Kettyle LM, Zhang D, O'Mahony A, Gracias D, McCall L, Westwood R, Terstappen GC, Davies SG, Tate EW, Wynne GM, Vyas P, Russell AJ, Milne TA.
Jackson TR, et al. Among authors: vuorinen a.
iScience. 2022 Jul 19;25(8):104787. doi: 10.1016/j.isci.2022.104787. eCollection 2022 Aug 19.
iScience. 2022.
PMID: 35992086
Free PMC article.
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Profiling Sulfur(VI) Fluorides as Reactive Functionalities for Chemical Biology Tools and Expansion of the Ligandable Proteome.
Gilbert KE, Vuorinen A, Aatkar A, Pogány P, Pettinger J, Grant EK, Kirkpatrick JM, Rittinger K, House D, Burley GA, Bush JT.
Gilbert KE, et al. Among authors: vuorinen a.
ACS Chem Biol. 2023 Feb 17;18(2):285-295. doi: 10.1021/acschembio.2c00633. Epub 2023 Jan 17.
ACS Chem Biol. 2023.
PMID: 36649130
Free PMC article.
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Discovery and mechanism of action studies of 4,6-diphenylpyrimidine-2-carbohydrazides as utrophin modulators for the treatment of Duchenne muscular dystrophy.
Vuorinen A, Wilkinson IVL, Chatzopoulou M, Edwards B, Squire SE, Fairclough RJ, Bazan NA, Milner JA, Conole D, Donald JR, Shah N, Willis NJ, Martínez RF, Wilson FX, Wynne GM, Davies SG, Davies KE, Russell AJ.
Vuorinen A, et al.
Eur J Med Chem. 2021 Aug 5;220:113431. doi: 10.1016/j.ejmech.2021.113431. Epub 2021 Apr 20.
Eur J Med Chem. 2021.
PMID: 33915371
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Chemical Proteomics and Phenotypic Profiling Identifies the Aryl Hydrocarbon Receptor as a Molecular Target of the Utrophin Modulator Ezutromid.
Wilkinson IVL, Perkins KJ, Dugdale H, Moir L, Vuorinen A, Chatzopoulou M, Squire SE, Monecke S, Lomow A, Geese M, Charles PD, Burch P, Tinsley JM, Wynne GM, Davies SG, Wilson FX, Rastinejad F, Mohammed S, Davies KE, Russell AJ.
Wilkinson IVL, et al. Among authors: vuorinen a.
Angew Chem Int Ed Engl. 2020 Feb 3;59(6):2420-2428. doi: 10.1002/anie.201912392. Epub 2020 Jan 3.
Angew Chem Int Ed Engl. 2020.
PMID: 31755636
Free PMC article.
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Cross-dehydrogenative couplings between indoles and β-keto esters: ligand-assisted ligand tautomerization and dehydrogenation via a proton-assisted electron transfer to Pd(II).
Leskinen MV, Madarász Á, Yip KT, Vuorinen A, Pápai I, Neuvonen AJ, Pihko PM.
Leskinen MV, et al. Among authors: vuorinen a.
J Am Chem Soc. 2014 Apr 30;136(17):6453-62. doi: 10.1021/ja501681y. Epub 2014 Apr 16.
J Am Chem Soc. 2014.
PMID: 24684203
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