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The GDF15-GFRAL pathway is dispensable for the effects of metformin on energy balance.
Klein AB, Nicolaisen TS, Johann K, Fritzen AM, Mathiesen CV, Gil C, Pilmark NS, Karstoft K, Blond MB, Quist JS, Seeley RJ, Færch K, Lund J, Kleinert M, Clemmensen C. Klein AB, et al. Among authors: pilmark ns. Cell Rep. 2022 Aug 23;40(8):111258. doi: 10.1016/j.celrep.2022.111258. Cell Rep. 2022. PMID: 36001956 Free article.
Redox state and altered pyruvate metabolism contribute to a dose-dependent metformin-induced lactate production of human myotubes.
Maurer J, Zhao X, Irmler M, Gudiksen A, Pilmark NS, Li Q, Goj T, Beckers J, Hrabě de Angelis M, Birkenfeld AL, Peter A, Lehmann R, Pilegaard H, Karstoft K, Xu G, Weigert C. Maurer J, et al. Among authors: pilmark ns. Am J Physiol Cell Physiol. 2023 Oct 1;325(4):C1131-C1143. doi: 10.1152/ajpcell.00186.2023. Epub 2023 Sep 11. Am J Physiol Cell Physiol. 2023. PMID: 37694284 Free PMC article.
Type 2 diabetes remission 1 year after an intensive lifestyle intervention: A secondary analysis of a randomized clinical trial.
Ried-Larsen M, Johansen MY, MacDonald CS, Hansen KB, Christensen R, Wedell-Neergaard AS, Pilmark NS, Langberg H, Vaag AA, Pedersen BK, Karstoft K. Ried-Larsen M, et al. Diabetes Obes Metab. 2019 Oct;21(10):2257-2266. doi: 10.1111/dom.13802. Epub 2019 Jun 30. Diabetes Obes Metab. 2019. PMID: 31168922 Free PMC article. Clinical Trial.
Skeletal muscle adaptations to exercise are not influenced by metformin treatment in humans: secondary analyses of 2 randomized, clinical trials.
Pilmark NS, Oberholzer L, Halling JF, Kristensen JM, Bønding CP, Elkjær I, Lyngbæk M, Elster G, Siebenmann C, Holm NFR, Birk JB, Larsen EL, Lundby AM, Wojtaszewski J, Pilegaard H, Poulsen HE, Pedersen BK, Hansen KB, Karstoft K. Pilmark NS, et al. Appl Physiol Nutr Metab. 2022 Mar;47(3):309-320. doi: 10.1139/apnm-2021-0194. Epub 2021 Nov 16. Appl Physiol Nutr Metab. 2022. PMID: 34784247 Clinical Trial.
The interaction between metformin and physical activity on postprandial glucose and glucose kinetics: a randomised, clinical trial.
Pilmark NS, Lyngbæk M, Oberholzer L, Elkjær I, Petersen-Bønding C, Kofoed K, Siebenmann C, Kellenberger K, van Hall G, Abildgaard J, Ellingsgaard H, Lauridsen C, Ried-Larsen M, Pedersen BK, Hansen KB, Karstoft K. Pilmark NS, et al. Diabetologia. 2021 Feb;64(2):397-409. doi: 10.1007/s00125-020-05282-6. Epub 2020 Sep 26. Diabetologia. 2021. PMID: 32979074 Clinical Trial.