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Intratumoral co-injection of NK cells and NKG2A-neutralizing monoclonal antibodies.
Melero I, Ochoa MC, Molina C, Sanchez-Gregorio S, Garasa S, Luri-Rey C, Hervas-Stubbs S, Casares N, Elizalde E, Gomis G, Cirella A, Berraondo P, Teijeira A, Alvarez M. Melero I, et al. Among authors: elizalde e. EMBO Mol Med. 2023 Nov 8;15(11):e17804. doi: 10.15252/emmm.202317804. Epub 2023 Oct 2. EMBO Mol Med. 2023. PMID: 37782273 Free PMC article.
Epitope spreading driven by the joint action of CART cells and pharmacological STING stimulation counteracts tumor escape via antigen-loss variants.
Conde E, Vercher E, Soria-Castellano M, Suarez-Olmos J, Mancheño U, Elizalde E, Rodriguez ML, Glez-Vaz J, Casares N, Rodríguez-García E, Hommel M, González-Aseguinolaza G, Uranga-Murillo I, Pardo J, Alkorta G, Melero I, Lasarte J, Hervas-Stubbs S. Conde E, et al. Among authors: elizalde e. J Immunother Cancer. 2021 Nov;9(11):e003351. doi: 10.1136/jitc-2021-003351. J Immunother Cancer. 2021. PMID: 34810235 Free PMC article.
The mutational load and a T-cell inflamed tumour phenotype identify ovarian cancer patients rendering tumour-reactive T cells from PD-1+ tumour-infiltrating lymphocytes.
Salas-Benito D, Conde E, Tamayo-Uria I, Mancheño U, Elizalde E, Garcia-Ros D, Aramendia JM, Muruzabal JC, Alcaide J, Guillen-Grima F, Minguez JA, Amores-Tirado J, Gonzalez-Martin A, Sarobe P, Lasarte JJ, Ponz-Sarvise M, De Andrea CE, Hervas-Stubbs S. Salas-Benito D, et al. Among authors: elizalde e. Br J Cancer. 2021 Mar;124(6):1138-1149. doi: 10.1038/s41416-020-01218-4. Epub 2021 Jan 5. Br J Cancer. 2021. PMID: 33402737 Free PMC article.
FOXP3 expression diversifies the metabolic capacity and enhances the efficacy of CD8 T cells in adoptive immunotherapy of melanoma.
Conde E, Casares N, Mancheño U, Elizalde E, Vercher E, Capozzi R, Santamaria E, Rodriguez-Madoz JR, Prosper F, Lasarte JJ, Lozano T, Hervas-Stubbs S. Conde E, et al. Among authors: elizalde e. Mol Ther. 2023 Jan 4;31(1):48-65. doi: 10.1016/j.ymthe.2022.08.017. Epub 2022 Aug 31. Mol Ther. 2023. PMID: 36045586 Free PMC article.
Expansion of Tumor-Infiltrating CD8+ T cells Expressing PD-1 Improves the Efficacy of Adoptive T-cell Therapy.
Fernandez-Poma SM, Salas-Benito D, Lozano T, Casares N, Riezu-Boj JI, Mancheño U, Elizalde E, Alignani D, Zubeldia N, Otano I, Conde E, Sarobe P, Lasarte JJ, Hervas-Stubbs S. Fernandez-Poma SM, et al. Among authors: elizalde e. Cancer Res. 2017 Jul 1;77(13):3672-3684. doi: 10.1158/0008-5472.CAN-17-0236. Epub 2017 May 18. Cancer Res. 2017. PMID: 28522749