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Page 1
Role of Plasma Membrane Dicarboxylate Transporters in the Uptake and Toxicity of Diglycolic Acid, a Metabolite of Diethylene Glycol, in Human Proximal Tubule Cells.
Toxicol Sci. 2022 Oct 27;190(1):1-12. doi: 10.1093/toxsci/kfac091.
Toxicol Sci. 2022.
PMID: 36087010
Lack of efflux of diglycolic acid from proximal tubule cells leads to its accumulation and to toxicity of diethylene glycol.
Tobin JD, Robinson CN, Luttrell-Williams ES, Landry GM, McMartin KE.
Tobin JD, et al. Among authors: robinson cn.
Toxicol Lett. 2023 Apr 15;379:48-55. doi: 10.1016/j.toxlet.2023.03.007. Epub 2023 Mar 22.
Toxicol Lett. 2023.
PMID: 36958672
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Variable sensitivity to diethylene glycol poisoning is related to differences in the uptake transporter for the toxic metabolite diglycolic acid.
Tobin JD, Jamison CN, Robinson CN, McMartin KE.
Tobin JD, et al. Among authors: robinson cn.
Clin Toxicol (Phila). 2023 Apr;61(4):207-211. doi: 10.1080/15563650.2022.2163659. Epub 2023 Mar 20.
Clin Toxicol (Phila). 2023.
PMID: 36939119
Free PMC article.
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Nucleoside reverse transcriptase inhibitors induce a mitophagy-associated endothelial cytotoxicity that is reversed by coenzyme Q10 cotreatment.
Xue SY, Hebert VY, Hayes DM, Robinson CN, Glover M, Dugas TR.
Xue SY, et al. Among authors: robinson cn.
Toxicol Sci. 2013 Aug;134(2):323-34. doi: 10.1093/toxsci/kft105. Epub 2013 May 2.
Toxicol Sci. 2013.
PMID: 23640862
Free PMC article.
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In-vivo evidence of nephrotoxicity and altered hepatic function in rats following administration of diglycolic acid, a metabolite of diethylene glycol.
Robinson CN, Latimer B, Abreo F, Broussard K, McMartin KE.
Robinson CN, et al.
Clin Toxicol (Phila). 2017 Mar;55(3):196-205. doi: 10.1080/15563650.2016.1271128. Epub 2017 Jan 11.
Clin Toxicol (Phila). 2017.
PMID: 28074668
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