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Impaired skeletal muscle mitochondrial pyruvate uptake rewires glucose metabolism to drive whole-body leanness.
Sharma A, Oonthonpan L, Sheldon RD, Rauckhorst AJ, Zhu Z, Tompkins SC, Cho K, Grzesik WJ, Gray LR, Scerbo DA, Pewa AD, Cushing EM, Dyle MC, Cox JE, Adams C, Davies BS, Shields RK, Norris AW, Patti G, Zingman LV, Taylor EB. Sharma A, et al. Among authors: scerbo da. Elife. 2019 Jul 18;8:e45873. doi: 10.7554/eLife.45873. Elife. 2019. PMID: 31305240 Free PMC article.
Cardiac myocyte KLF5 regulates body weight via alteration of cardiac FGF21.
Pol CJ, Pollak NM, Jurczak MJ, Zacharia E, Karagiannides I, Kyriazis ID, Ntziachristos P, Scerbo DA, Brown BR, Aifantis I, Shulman GI, Goldberg IJ, Drosatos K. Pol CJ, et al. Among authors: scerbo da. Biochim Biophys Acta Mol Basis Dis. 2019 Sep 1;1865(9):2125-2137. doi: 10.1016/j.bbadis.2019.04.010. Epub 2019 Apr 26. Biochim Biophys Acta Mol Basis Dis. 2019. PMID: 31029826 Free PMC article.
Disrupting Mitochondrial Pyruvate Uptake Directs Glutamine into the TCA Cycle away from Glutathione Synthesis and Impairs Hepatocellular Tumorigenesis.
Tompkins SC, Sheldon RD, Rauckhorst AJ, Noterman MF, Solst SR, Buchanan JL, Mapuskar KA, Pewa AD, Gray LR, Oonthonpan L, Sharma A, Scerbo DA, Dupuy AJ, Spitz DR, Taylor EB. Tompkins SC, et al. Among authors: scerbo da. Cell Rep. 2019 Sep 3;28(10):2608-2619.e6. doi: 10.1016/j.celrep.2019.07.098. Cell Rep. 2019. PMID: 31484072 Free PMC article.