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Page 1
EWS/FLI mediated reprogramming of 3D chromatin promotes an altered transcriptional state in Ewing sarcoma.
Nucleic Acids Res. 2022 Sep 23;50(17):9814-9837. doi: 10.1093/nar/gkac747.
Nucleic Acids Res. 2022.
PMID: 36124657
Free PMC article.
Mapping the Structure-Function Relationships of Disordered Oncogenic Transcription Factors Using Transcriptomic Analysis.
Showpnil IA, Miller KR, Taslim C, Pishas KI, Lessnick SL, Theisen ER.
Showpnil IA, et al.
J Vis Exp. 2020 Jun 27;(160):10.3791/61564. doi: 10.3791/61564.
J Vis Exp. 2020.
PMID: 32658189
Free PMC article.
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The FLI portion of EWS/FLI contributes a transcriptional regulatory function that is distinct and separable from its DNA-binding function in Ewing sarcoma.
Boone MA, Taslim C, Crow JC, Selich-Anderson J, Byrum AK, Showpnil IA, Sunkel BD, Wang M, Stanton BZ, Theisen ER, Lessnick SL.
Boone MA, et al. Among authors: showpnil ia.
Oncogene. 2021 Jul;40(29):4759-4769. doi: 10.1038/s41388-021-01876-5. Epub 2021 Jun 18.
Oncogene. 2021.
PMID: 34145397
Free PMC article.
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The DBD-α4 helix of EWS::FLI is required for GGAA microsatellite binding that underlies genome regulation in Ewing sarcoma.
Bayanjargal A, Taslim C, Showpnil IA, Selich-Anderson J, Crow JC, Lessnick SL, Theisen ER.
Bayanjargal A, et al. Among authors: showpnil ia.
bioRxiv [Preprint]. 2024 Jan 31:2024.01.31.578127. doi: 10.1101/2024.01.31.578127.
bioRxiv. 2024.
PMID: 38352344
Free PMC article.
Preprint.
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Transcriptomic analysis functionally maps the intrinsically disordered domain of EWS/FLI and reveals novel transcriptional dependencies for oncogenesis.
Theisen ER, Miller KR, Showpnil IA, Taslim C, Pishas KI, Lessnick SL.
Theisen ER, et al. Among authors: showpnil ia.
Genes Cancer. 2019 Feb;10(1-2):21-38. doi: 10.18632/genesandcancer.188.
Genes Cancer. 2019.
PMID: 30899417
Free PMC article.
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