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USP7 inhibitors suppress tumour neoangiogenesis and promote synergy with immune checkpoint inhibitors by downregulating fibroblast VEGF.
Jurisic A, Sung PJ, Wappett M, Daubriac J, Lobb IT, Kung WW, Crawford N, Page N, Cassidy E, Feutren-Burton S, Rountree JSS, Helm MD, O'Dowd CR, Kennedy RD, Gavory G, Cranston AN, Longley DB, Jacq X, Harrison T. Jurisic A, et al. Among authors: rountree jss. Clin Transl Med. 2024 Apr;14(4):e1648. doi: 10.1002/ctm2.1648. Clin Transl Med. 2024. PMID: 38602256 Free PMC article.
Identification and Structure-Guided Development of Pyrimidinone Based USP7 Inhibitors.
O'Dowd CR, Helm MD, Rountree JSS, Flasz JT, Arkoudis E, Miel H, Hewitt PR, Jordan L, Barker O, Hughes C, Rozycka E, Cassidy E, McClelland K, Odrzywol E, Page N, Feutren-Burton S, Dvorkin S, Gavory G, Harrison T. O'Dowd CR, et al. Among authors: rountree jss. ACS Med Chem Lett. 2018 Feb 21;9(3):238-243. doi: 10.1021/acsmedchemlett.7b00512. eCollection 2018 Mar 8. ACS Med Chem Lett. 2018. PMID: 29541367 Free PMC article.