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Page 1
Location bias: A "Hidden Variable" in GPCR pharmacology.
Bioessays. 2023 Nov;45(11):e2300123. doi: 10.1002/bies.202300123. Epub 2023 Aug 25.
Bioessays. 2023.
PMID: 37625014
Biased agonism at chemokine receptors.
Eiger DS, Boldizsar N, Honeycutt CC, Gardner J, Rajagopal S.
Eiger DS, et al.
Cell Signal. 2021 Feb;78:109862. doi: 10.1016/j.cellsig.2020.109862. Epub 2020 Nov 27.
Cell Signal. 2021.
PMID: 33249087
Free PMC article.
Item in Clipboard
GPCR systems pharmacology: a different perspective on the development of biased therapeutics.
Eiger DS, Pham U, Gardner J, Hicks C, Rajagopal S.
Eiger DS, et al.
Am J Physiol Cell Physiol. 2022 May 1;322(5):C887-C895. doi: 10.1152/ajpcell.00449.2021. Epub 2022 Feb 23.
Am J Physiol Cell Physiol. 2022.
PMID: 35196164
Free PMC article.
Review.
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Location bias contributes to functionally selective responses of biased CXCR3 agonists.
Eiger DS, Boldizsar N, Honeycutt CC, Gardner J, Kirchner S, Hicks C, Choi I, Pham U, Zheng K, Warman A, Smith JS, Zhang JY, Rajagopal S.
Eiger DS, et al.
Nat Commun. 2022 Oct 4;13(1):5846. doi: 10.1038/s41467-022-33569-2.
Nat Commun. 2022.
PMID: 36195635
Free PMC article.
Item in Clipboard
GPCR kinases differentially modulate biased signaling downstream of CXCR3 depending on their subcellular localization.
Gardner J, Eiger DS, Hicks C, Choi I, Pham U, Chundi A, Namjoshi O, Rajagopal S.
Gardner J, et al. Among authors: eiger ds.
Sci Signal. 2024 Feb 13;17(823):eadd9139. doi: 10.1126/scisignal.add9139. Epub 2024 Feb 13.
Sci Signal. 2024.
PMID: 38349966
Free PMC article.
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ACKR3 Proximity Labeling Identifies Novel G protein- and β-arrestin-independent GPCR Interacting Proteins.
Hicks C, Gardner J, Eiger DS, Camarda ND, Pham U, Dhar S, Rodriguez H, Chundi A, Rajagopal S.
Hicks C, et al. Among authors: eiger ds.
bioRxiv [Preprint]. 2024 Jan 28:2024.01.27.577545. doi: 10.1101/2024.01.27.577545.
bioRxiv. 2024.
PMID: 38410489
Free PMC article.
Preprint.
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