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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1966 1
1968 2
1969 4
1970 2
1971 4
1972 4
1973 3
1974 11
1975 24
1976 12
1977 16
1978 12
1979 13
1980 14
1981 18
1982 29
1983 31
1984 36
1985 38
1986 47
1987 67
1988 66
1989 77
1990 111
1991 136
1992 164
1993 187
1994 222
1995 249
1996 282
1997 332
1998 308
1999 358
2000 431
2001 523
2002 610
2003 678
2004 888
2005 1087
2006 1183
2007 1426
2008 1658
2009 1804
2010 2149
2011 2600
2012 2953
2013 3345
2014 3923
2015 4289
2016 4536
2017 4723
2018 5760
2019 6565
2020 7362
2021 8258
2022 9596
2023 9651
2024 4868

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82,570 results

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Page 1
Chemical Components of Ganoderma.
Gong T, Yan R, Kang J, Chen R. Gong T, et al. Among authors: chen r. Adv Exp Med Biol. 2019;1181:59-106. doi: 10.1007/978-981-13-9867-4_3. Adv Exp Med Biol. 2019. PMID: 31677140 Review.
So far, more than 20 species of Ganoderma (Lingzhi) fungi have been studied, including G. lucidum, G. sinense, G. japonicum, G. capense, G. australe, G. tsugae, G. applanatum, G. tropicus, G. boniense, G. durop …
So far, more than 20 species of Ganoderma (Lingzhi) fungi have been studied, including G. lucidum, G. sinense, G. japon …
Scleromyxedema.
Yang Y, Chen H, Zhang W, Sun JF. Yang Y, et al. Among authors: chen h. Indian J Dermatol Venereol Leprol. 2016 Nov-Dec;82(6):738-739. doi: 10.4103/0378-6323.174420. Indian J Dermatol Venereol Leprol. 2016. PMID: 26858056 Free article. No abstract available.
Effects of Exercise Training Interventions on Executive Function in Older Adults: A Systematic Review and Meta-Analysis.
Chen FT, Etnier JL, Chan KH, Chiu PK, Hung TM, Chang YK. Chen FT, et al. Sports Med. 2020 Aug;50(8):1451-1467. doi: 10.1007/s40279-020-01292-x. Sports Med. 2020. PMID: 32447717 Free PMC article.

Regarding exercise prescription variables, results were significantly moderated by frequency of exercise training [Q(1) = 10.86, p < 0.05], revealing that effect sizes (ESs) were larger for moderate frequency (g = 0.31) as compared to low frequency exercise (g =

…

Regarding exercise prescription variables, results were significantly moderated by frequency of exercise training [Q(1) = 10.86, p < 0.05

…
G-quadruplex ligands inhibit chikungunya virus replication.
Lv L, Cui H, Chen Z, Zhou Y, Zhang L. Lv L, et al. Among authors: chen z. J Med Virol. 2022 Jun;94(6):2519-2527. doi: 10.1002/jmv.27622. Epub 2022 Feb 2. J Med Virol. 2022. PMID: 35075669
In this study, we show that the CHIKV genome possesses several conserved potential G-quadruplex sequences. G-quadruplex ligands BRACO-19 and TMPyP4 could stabilize the CHIKV G-quadruplex and inhibit the transcription of constructs containing CHIKV G-qu …
In this study, we show that the CHIKV genome possesses several conserved potential G-quadruplex sequences. G-quadruplex ligand …
Small-molecule targeting of GPCR-independent noncanonical G-protein signaling in cancer.
Zhao J, DiGiacomo V, Ferreras-Gutierrez M, Dastjerdi S, Ibáñez de Opakua A, Park JC, Luebbers A, Chen Q, Beeler A, Blanco FJ, Garcia-Marcos M. Zhao J, et al. Among authors: chen q. Proc Natl Acad Sci U S A. 2023 May 2;120(18):e2213140120. doi: 10.1073/pnas.2213140120. Epub 2023 Apr 25. Proc Natl Acad Sci U S A. 2023. PMID: 37098067 Free PMC article.
Activation of heterotrimeric G-proteins (Galphabetagamma) by G-protein-coupled receptors (GPCRs) is a quintessential mechanism of cell signaling widely targeted by clinically approved drugs. ...In contrast, IGGi-11 did not interfere with canonical G-protein s …
Activation of heterotrimeric G-proteins (Galphabetagamma) by G-protein-coupled receptors (GPCRs) is a quintessential mechanism …
G protein-coupled receptor interactions with arrestins and GPCR kinases: The unresolved issue of signal bias.
Chen Q, Tesmer JJG. Chen Q, et al. J Biol Chem. 2022 Sep;298(9):102279. doi: 10.1016/j.jbc.2022.102279. Epub 2022 Jul 19. J Biol Chem. 2022. PMID: 35863432 Free PMC article. Review.
G protein-coupled receptor (GPCR) kinases (GRKs) and arrestins interact with agonist-bound GPCRs to promote receptor desensitization and downregulation. They also trigger signaling cascades distinct from those of heterotrimeric G proteins. Biased agonists for GPCRs …
G protein-coupled receptor (GPCR) kinases (GRKs) and arrestins interact with agonist-bound GPCRs to promote receptor desensitization …
Activation of G-protein-coupled receptor 183 initiates inflammatory pain via macrophage CCL22 secretion.
Qi Z, Zhong W, Jiao B, Chen K, Yang X, Wang L, Zeng W, Huang J, Xie J. Qi Z, et al. Among authors: chen k. Eur J Pharmacol. 2023 Sep 5;954:175872. doi: 10.1016/j.ejphar.2023.175872. Epub 2023 Jun 21. Eur J Pharmacol. 2023. PMID: 37353188
Chronic pain is a major public health problem with limited effective therapeutic options. G-protein-coupled receptors play a significant role in pain modulation; however, whether and how G-protein-coupled receptor 183 participates in pain regulation remain unclear. …
Chronic pain is a major public health problem with limited effective therapeutic options. G-protein-coupled receptors play a signific …
Recent advances in fluorescent probes for G-quadruplex nucleic acids.
Yuan JH, Shao W, Chen SB, Huang ZS, Tan JH. Yuan JH, et al. Among authors: chen sb. Biochem Biophys Res Commun. 2020 Oct 8;531(1):18-24. doi: 10.1016/j.bbrc.2020.02.114. Epub 2020 Feb 25. Biochem Biophys Res Commun. 2020. PMID: 32111356 Review.
G-quadruplexes are non-canonical nucleic acid structures formed by guanine-rich DNA or RNA sequences. ...Therefore, to further study the function and distribution of G-quadruplexes, developing new probes is an essential part of G-quadruplexes research. ...
G-quadruplexes are non-canonical nucleic acid structures formed by guanine-rich DNA or RNA sequences. ...Therefore, to further study …
Heterotrimeric G-proteins in plant development.
Chen JG. Chen JG. Front Biosci. 2008 May 1;13:3321-33. doi: 10.2741/2928. Front Biosci. 2008. PMID: 18508435 Review.
Signaling through heterotrimeric G-proteins (G-proteins) is a conserved mechanism found in all eukaryotes. In plants, the repertoire of G-protein signaling complex is much simpler than in metazoans. ...
Signaling through heterotrimeric G-proteins (G-proteins) is a conserved mechanism found in all eukaryotes. In plants, the repe …
Structural insights into adhesion GPCR ADGRL3 activation and G(q), G(s), G(i), and G(12) coupling.
Qian Y, Ma Z, Liu C, Li X, Zhu X, Wang N, Xu Z, Xia R, Liang J, Duan Y, Yin H, Xiong Y, Zhang A, Guo C, Chen Z, Huang Z, He Y. Qian Y, et al. Among authors: chen z. Mol Cell. 2022 Nov 17;82(22):4340-4352.e6. doi: 10.1016/j.molcel.2022.10.009. Epub 2022 Oct 28. Mol Cell. 2022. PMID: 36309016 Free article.
Here, we present cryoelectron microscopy (cryo-EM) structures of ADGRL3 in complex with G(q), G(s), G(i), and G(12). The structures reveal unique ligand-engaging mode, distinctive activation conformation, and key mechanisms of aGPCR activation. The str …
Here, we present cryoelectron microscopy (cryo-EM) structures of ADGRL3 in complex with G(q), G(s), G(i), and G( …
82,570 results
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