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AKT-mTORC1 reactivation is the dominant resistance driver for PI3Kβ/AKT inhibitors in PTEN-null breast cancer and can be overcome by combining with Mcl-1 inhibitors.
Oncogene. 2022 Nov;41(46):5046-5060. doi: 10.1038/s41388-022-02482-9. Epub 2022 Oct 14.
Oncogene. 2022.
PMID: 36241868
Free PMC article.
Class IA PI3K regulatory subunits: p110-independent roles and structures.
Fox M, Mott HR, Owen D.
Fox M, et al.
Biochem Soc Trans. 2020 Aug 28;48(4):1397-1417. doi: 10.1042/BST20190845.
Biochem Soc Trans. 2020.
PMID: 32677674
Free PMC article.
Review.
Item in Clipboard
The non-receptor tyrosine kinase ACK: regulatory mechanisms, signalling pathways and opportunities for attACKing cancer.
Fox M, Crafter C, Owen D.
Fox M, et al.
Biochem Soc Trans. 2019 Dec 20;47(6):1715-1731. doi: 10.1042/BST20190176.
Biochem Soc Trans. 2019.
PMID: 31845724
Review.
Item in Clipboard
ACKnowledging the role of the Activated-Cdc42 associated kinase (ACK) in regulating protein stability in cancer.
Hodder S, Fox M, Binti Ahmad Mokhtar AM, Mott HR, Owen D.
Hodder S, et al. Among authors: fox m.
Small GTPases. 2023 Dec;14(1):14-25. doi: 10.1080/21541248.2023.2212573.
Small GTPases. 2023.
PMID: 37194323
Free PMC article.
Review.
Item in Clipboard
Assembly of nuclear dimers of PI3K regulatory subunits is regulated by the Cdc42-activated tyrosine kinase ACK.
Clayton NS, Fox M, Vicenté-Garcia JJ, Schroeder CM, Littlewood TD, Wilde JI, Krishnan K, Brown MJB, Crafter C, Mott HR, Owen D.
Clayton NS, et al. Among authors: fox m.
J Biol Chem. 2022 Jun;298(6):101916. doi: 10.1016/j.jbc.2022.101916. Epub 2022 Apr 13.
J Biol Chem. 2022.
PMID: 35429500
Free PMC article.
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