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ClampFISH 2.0 enables rapid, scalable amplified RNA detection in situ.
Dardani I, Emert BL, Goyal Y, Jiang CL, Kaur A, Lee J, Rouhanifard SH, Alicea GM, Fane ME, Xiao M, Herlyn M, Weeraratna AT, Raj A. Dardani I, et al. Among authors: jiang cl. Nat Methods. 2022 Nov;19(11):1403-1410. doi: 10.1038/s41592-022-01653-6. Epub 2022 Oct 24. Nat Methods. 2022. PMID: 36280724 Free PMC article.
Genetic screening for single-cell variability modulators driving therapy resistance.
Torre EA, Arai E, Bayatpour S, Jiang CL, Beck LE, Emert BL, Shaffer SM, Mellis IA, Fane ME, Alicea GM, Budinich KA, Weeraratna AT, Shi J, Raj A. Torre EA, et al. Among authors: jiang cl. Nat Genet. 2021 Jan;53(1):76-85. doi: 10.1038/s41588-020-00749-z. Epub 2021 Jan 4. Nat Genet. 2021. PMID: 33398196 Free PMC article.
ClampFISH detects individual nucleic acid molecules using click chemistry-based amplification.
Rouhanifard SH, Mellis IA, Dunagin M, Bayatpour S, Jiang CL, Dardani I, Symmons O, Emert B, Torre E, Cote A, Sullivan A, Stamatoyannopoulos JA, Raj A. Rouhanifard SH, et al. Among authors: jiang cl. Nat Biotechnol. 2018 Nov 12:10.1038/nbt.4286. doi: 10.1038/nbt.4286. Online ahead of print. Nat Biotechnol. 2018. PMID: 30418432 Free PMC article.