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KIF2A deficiency causes early-onset neurodegeneration.
Ruiz-Reig N, Chehade G, Hakanen J, Aittaleb M, Wierda K, De Wit J, Nguyen L, Gailly P, Tissir F. Ruiz-Reig N, et al. Among authors: hakanen j. Proc Natl Acad Sci U S A. 2022 Nov 16;119(46):e2209714119. doi: 10.1073/pnas.2209714119. Epub 2022 Nov 7. Proc Natl Acad Sci U S A. 2022. PMID: 36343267 Free PMC article.
The Celsr3-Kif2a axis directs neuronal migration in the postnatal brain.
Hakanen J, Parmentier N, Sommacal L, Garcia-Sanchez D, Aittaleb M, Vertommen D, Zhou L, Ruiz-Reig N, Tissir F. Hakanen J, et al. Prog Neurobiol. 2022 Jan;208:102177. doi: 10.1016/j.pneurobio.2021.102177. Epub 2021 Sep 25. Prog Neurobiol. 2022. PMID: 34582949
Pinkbar is an epithelial-specific BAR domain protein that generates planar membrane structures.
Pykäläinen A, Boczkowska M, Zhao H, Saarikangas J, Rebowski G, Jansen M, Hakanen J, Koskela EV, Peränen J, Vihinen H, Jokitalo E, Salminen M, Ikonen E, Dominguez R, Lappalainen P. Pykäläinen A, et al. Among authors: hakanen j. Nat Struct Mol Biol. 2011 Jul 10;18(8):902-7. doi: 10.1038/nsmb.2079. Nat Struct Mol Biol. 2011. PMID: 21743456 Free PMC article.
Missing-in-metastasis MIM/MTSS1 promotes actin assembly at intercellular junctions and is required for integrity of kidney epithelia.
Saarikangas J, Mattila PK, Varjosalo M, Bovellan M, Hakanen J, Calzada-Wack J, Tost M, Jennen L, Rathkolb B, Hans W, Horsch M, Hyvönen ME, Perälä N, Fuchs H, Gailus-Durner V, Esposito I, Wolf E, de Angelis MH, Frilander MJ, Savilahti H, Sariola H, Sainio K, Lehtonen S, Taipale J, Salminen M, Lappalainen P. Saarikangas J, et al. Among authors: hakanen j. J Cell Sci. 2011 Apr 15;124(Pt 8):1245-55. doi: 10.1242/jcs.082610. Epub 2011 Mar 15. J Cell Sci. 2011. PMID: 21406566