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The PIP4K2 inhibitor THZ-P1-2 exhibits antileukemia activity by disruption of mitochondrial homeostasis and autophagy.
Lima K, Pereira-Martins DA, de Miranda LBL, Coelho-Silva JL, Leandro GDS, Weinhäuser I, Cavaglieri RC, Leal AM, da Silva WF, Lange APAL, Velloso EDRP, Griessinger E, Hilberink JR, Ammatuna E, Huls G, Schuringa JJ, Rego EM, Machado-Neto JA. Lima K, et al. Among authors: lange apal. Blood Cancer J. 2022 Nov 9;12(11):151. doi: 10.1038/s41408-022-00747-w. Blood Cancer J. 2022. PMID: 36347832 Free PMC article.
The CEBPA gene is down-regulated in acute promyelocytic leukemia and its upstream promoter, but not the core promoter, is highly methylated.
Santana-Lemos BA, de Lima Lange AP, de Lira Benício MT, José TD, Lucena-Araújo AR, Krause A, Thomé CH, Rego EM. Santana-Lemos BA, et al. Among authors: de lima lange ap. Haematologica. 2011 Apr;96(4):617-20. doi: 10.3324/haematol.2010.028365. Epub 2010 Dec 6. Haematologica. 2011. PMID: 21134977 Free PMC article.