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Pooled screening of CAR T cells identifies diverse immune signaling domains for next-generation immunotherapies.
Goodman DB, Azimi CS, Kearns K, Talbot A, Garakani K, Garcia J, Patel N, Hwang B, Lee D, Park E, Vykunta VS, Shy BR, Ye CJ, Eyquem J, Marson A, Bluestone JA, Roybal KT. Goodman DB, et al. Among authors: kearns k. Sci Transl Med. 2022 Nov 9;14(670):eabm1463. doi: 10.1126/scitranslmed.abm1463. Epub 2022 Nov 9. Sci Transl Med. 2022. PMID: 36350984 Free PMC article.
Antigen-specificity measurements are the key to understanding T cell responses.
Tippalagama R, Chihab LY, Kearns K, Lewis S, Panda S, Willemsen L, Burel JG, Lindestam Arlehamn CS. Tippalagama R, et al. Among authors: kearns k. Front Immunol. 2023 Apr 14;14:1127470. doi: 10.3389/fimmu.2023.1127470. eCollection 2023. Front Immunol. 2023. PMID: 37122719 Free PMC article. Review.
Specific gene repression by CRISPRi system transferred through bacterial conjugation.
Ji W, Lee D, Wong E, Dadlani P, Dinh D, Huang V, Kearns K, Teng S, Chen S, Haliburton J, Heimberg G, Heineike B, Ramasubramanian A, Stevens T, Helmke KJ, Zepeda V, Qi LS, Lim WA. Ji W, et al. Among authors: kearns k. ACS Synth Biol. 2014 Dec 19;3(12):929-31. doi: 10.1021/sb500036q. Epub 2014 Dec 6. ACS Synth Biol. 2014. PMID: 25409531 Free PMC article.