Not only mutations but also tumorigenesis can be substantially attributed to DNA damage from reactive oxygen species in RUNX1::RUNX1T1-fusion-positive acute myeloid leukemia

Leukemia. 2022 Dec;36(12):2931-2933. doi: 10.1038/s41375-022-01752-5. Epub 2022 Nov 11.
No abstract available

Publication types

  • Letter
  • Research Support, N.I.H., Extramural

MeSH terms

  • Carcinogenesis / genetics
  • Core Binding Factor Alpha 2 Subunit* / genetics
  • DNA Damage / genetics
  • Humans
  • Leukemia, Myeloid, Acute* / genetics
  • Mutation
  • Oncogene Proteins, Fusion / genetics
  • RUNX1 Translocation Partner 1 Protein / genetics
  • Reactive Oxygen Species
  • Translocation, Genetic

Substances

  • Core Binding Factor Alpha 2 Subunit
  • Reactive Oxygen Species
  • RUNX1 Translocation Partner 1 Protein
  • Oncogene Proteins, Fusion
  • RUNX1T1 protein, human
  • RUNX1 protein, human