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Pediatric phase 2 trial of a WEE1 inhibitor, adavosertib (AZD1775), and irinotecan for relapsed neuroblastoma, medulloblastoma, and rhabdomyosarcoma.
Cancer. 2023 Jul 15;129(14):2245-2255. doi: 10.1002/cncr.34786. Epub 2023 Apr 20.
Cancer. 2023.
PMID: 37081608
Clinical Trial.
The children's brain tumor network (CBTN) - Accelerating research in pediatric central nervous system tumors through collaboration and open science.
Lilly JV, Rokita JL, Mason JL, Patton T, Stefankiewiz S, Higgins D, Trooskin G, Larouci CA, Arya K, Appert E, Heath AP, Zhu Y, Brown MA, Zhang B, Farrow BK, Robins S, Morgan AM, Nguyen TQ, Frenkel E, Lehmann K, Drake E, Sullivan C, Plisiewicz A, Coleman N, Patterson L, Koptyra M, Helili Z, Van Kuren N, Young N, Kim MC, Friedman C, Lubneuski A, Blackden C, Williams M, Baubet V, Tauhid L, Galanaugh J, Boucher K, Ijaz H, Cole KA, Choudhari N, Santi M, Moulder RW, Waller J, Rife W, Diskin SJ, Mateos M, Parsons DW, Pollack IF, Goldman S, Leary S, Caporalini C, Buccoliero AM, Scagnet M, Haussler D, Hanson D, Firestein R, Cain J, Phillips JJ, Gupta N, Mueller S, Grant G, Monje-Deisseroth M, Partap S, Greenfield JP, Hashizume R, Smith A, Zhu S, Johnston JM, Fangusaro JR, Miller M, Wood MD, Gardner S, Carter CL, Prolo LM, Pisapia J, Pehlivan K, Franson A, Niazi T, Rubin J, Abdelbaki M, Ziegler DS, Lindsay HB, Stucklin AG, Gerber N, Vaske OM, Quinsey C, Rood BR, Nazarian J, Raabe E, Jackson EM, Stapleton S, Lober RM, Kram DE, Koschmann C, Storm PB, Lulla RR, Prados M, Resnick AC, Waanders AJ.
Lilly JV, et al. Among authors: ijaz h.
Neoplasia. 2023 Jan;35:100846. doi: 10.1016/j.neo.2022.100846. Epub 2022 Nov 3.
Neoplasia. 2023.
PMID: 36335802
Free PMC article.
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Alternative lengthening of telomeres (ALT) in pediatric high-grade gliomas can occur without ATRX mutation and is enriched in patients with pathogenic germline mismatch repair (MMR) variants.
Stundon JL, Ijaz H, Gaonkar KS, Kaufman RS, Jin R, Karras A, Vaksman Z, Kim J, Corbett RJ, Lueder MR, Miller DP, Guo Y, Santi M, Li M, Lopez G, Storm PB, Resnick AC, Waanders AJ, MacFarland SP, Stewart DR, Diskin SJ, Rokita JL, Cole KA.
Stundon JL, et al. Among authors: ijaz h.
Neuro Oncol. 2023 Jul 6;25(7):1331-1342. doi: 10.1093/neuonc/noac278.
Neuro Oncol. 2023.
PMID: 36541551
Free PMC article.
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Pediatric high-grade glioma resources from the Children's Brain Tumor Tissue Consortium.
Ijaz H, Koptyra M, Gaonkar KS, Rokita JL, Baubet VP, Tauhid L, Zhu Y, Brown M, Lopez G, Zhang B, Diskin SJ, Vaksman Z; Children’s Brain Tumor Tissue Consortium; Mason JL, Appert E, Lilly J, Lulla R, De Raedt T, Heath AP, Felmeister A, Raman P, Nazarian J, Santi MR, Storm PB, Resnick A, Waanders AJ, Cole KA.
Ijaz H, et al.
Neuro Oncol. 2020 Jan 11;22(1):163-165. doi: 10.1093/neuonc/noz192.
Neuro Oncol. 2020.
PMID: 31613963
Free PMC article.
No abstract available.
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SIRT1 activates the expression of fetal hemoglobin genes.
Dai Y, Chen T, Ijaz H, Cho EH, Steinberg MH.
Dai Y, et al. Among authors: ijaz h.
Am J Hematol. 2017 Nov;92(11):1177-1186. doi: 10.1002/ajh.24879. Epub 2017 Aug 28.
Am J Hematol. 2017.
PMID: 28776729
Free PMC article.
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Phase I Clinical Trial of the Wee1 Inhibitor Adavosertib (AZD1775) with Irinotecan in Children with Relapsed Solid Tumors: A COG Phase I Consortium Report (ADVL1312).
Cole KA, Pal S, Kudgus RA, Ijaz H, Liu X, Minard CG, Pawel BR, Maris JM, Haas-Kogan DA, Voss SD, Berg SL, Reid JM, Fox E, Weigel BJ.
Cole KA, et al. Among authors: ijaz h.
Clin Cancer Res. 2020 Mar 15;26(6):1213-1219. doi: 10.1158/1078-0432.CCR-19-3470. Epub 2019 Dec 19.
Clin Cancer Res. 2020.
PMID: 31857431
Free PMC article.
Clinical Trial.
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