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Page 1
Profiling mouse brown and white adipocytes to identify metabolically relevant small ORFs and functional microproteins.
Cell Metab. 2023 Jan 3;35(1):166-183.e11. doi: 10.1016/j.cmet.2022.12.004.
Cell Metab. 2023.
PMID: 36599300
Free PMC article.
NL-201 Upregulates MHC-I Expression and Intratumoral T-cell Receptor Diversity, and Demonstrates Robust Antitumor Activity as Monotherapy and in Combination with PD-1 Blockade.
Mortales C, Dutzar B, Chen J, Chen A, Huard J, Walkey C, Swanson R.
Mortales C, et al. Among authors: huard j.
Cancer Immunol Res. 2023 Jul 5;11(7):1000-1010. doi: 10.1158/2326-6066.CIR-22-0304.
Cancer Immunol Res. 2023.
PMID: 37129946
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Conatumumab, a fully human agonist antibody to death receptor 5, induces apoptosis via caspase activation in multiple tumor types.
Kaplan-Lefko PJ, Graves JD, Zoog SJ, Pan Y, Wall J, Branstetter DG, Moriguchi J, Coxon A, Huard JN, Xu R, Peach ML, Juan G, Kaufman S, Chen Q, Bianchi A, Kordich JJ, Ma M, Foltz IN, Gliniak BC.
Kaplan-Lefko PJ, et al. Among authors: huard jn.
Cancer Biol Ther. 2010 Apr 15;9(8):618-31. doi: 10.4161/cbt.9.8.11264. Epub 2010 Apr 20.
Cancer Biol Ther. 2010.
PMID: 20150762
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Discovery of AMG 925, a FLT3 and CDK4 dual kinase inhibitor with preferential affinity for the activated state of FLT3.
Li Z, Wang X, Eksterowicz J, Gribble MW Jr, Alba GQ, Ayres M, Carlson TJ, Chen A, Chen X, Cho R, Connors RV, DeGraffenreid M, Deignan JT, Duquette J, Fan P, Fisher B, Fu J, Huard JN, Kaizerman J, Keegan KS, Li C, Li K, Li Y, Liang L, Liu W, Lively SE, Lo MC, Ma J, McMinn DL, Mihalic JT, Modi K, Ngo R, Pattabiraman K, Piper DE, Queva C, Ragains ML, Suchomel J, Thibault S, Walker N, Wang X, Wang Z, Wanska M, Wehn PM, Weidner MF, Zhang AJ, Zhao X, Kamb A, Wickramasinghe D, Dai K, McGee LR, Medina JC.
Li Z, et al. Among authors: huard jn.
J Med Chem. 2014 Apr 24;57(8):3430-49. doi: 10.1021/jm500118j. Epub 2014 Apr 2.
J Med Chem. 2014.
PMID: 24641103
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Preclinical evaluation of AMG 925, a FLT3/CDK4 dual kinase inhibitor for treating acute myeloid leukemia.
Keegan K, Li C, Li Z, Ma J, Ragains M, Coberly S, Hollenback D, Eksterowicz J, Liang L, Weidner M, Huard J, Wang X, Alba G, Orf J, Lo MC, Zhao S, Ngo R, Chen A, Liu L, Carlson T, Quéva C, McGee LR, Medina J, Kamb A, Wickramasinghe D, Dai K.
Keegan K, et al. Among authors: huard j.
Mol Cancer Ther. 2014 Apr;13(4):880-9. doi: 10.1158/1535-7163.MCT-13-0858. Epub 2014 Feb 13.
Mol Cancer Ther. 2014.
PMID: 24526162
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Altering Antibody-Drug Conjugate Binding to the Neonatal Fc Receptor Impacts Efficacy and Tolerability.
Hamblett KJ, Le T, Rock BM, Rock DA, Siu S, Huard JN, Conner KP, Milburn RR, O'Neill JW, Tometsko ME, Fanslow WC.
Hamblett KJ, et al. Among authors: huard jn.
Mol Pharm. 2016 Jul 5;13(7):2387-96. doi: 10.1021/acs.molpharmaceut.6b00153. Epub 2016 Jun 13.
Mol Pharm. 2016.
PMID: 27248573
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FLT3 and CDK4/6 inhibitors: signaling mechanisms and tumor burden in subcutaneous and orthotopic mouse models of acute myeloid leukemia.
Zhang Y, Hsu CP, Lu JF, Kuchimanchi M, Sun YN, Ma J, Xu G, Zhang Y, Xu Y, Weidner M, Huard J, D'Argenio DZ.
Zhang Y, et al. Among authors: huard j.
J Pharmacokinet Pharmacodyn. 2014 Dec;41(6):675-91. doi: 10.1007/s10928-014-9393-x. Epub 2014 Oct 19.
J Pharmacokinet Pharmacodyn. 2014.
PMID: 25326874
Free PMC article.
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