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Year Number of Results
1983 2
1984 1
1985 1
1986 1
1988 4
1989 2
1990 1
1991 6
1992 3
1993 8
1994 14
1995 10
1996 11
1997 10
1998 16
1999 25
2000 24
2001 30
2002 30
2003 34
2004 45
2005 37
2006 69
2007 80
2008 93
2009 105
2010 110
2011 123
2012 144
2013 157
2014 188
2015 238
2016 291
2017 347
2018 470
2019 460
2020 533
2021 617
2022 718
2023 623
2024 358

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5,419 results

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Page 1
QKI shuttles internal m(7)G-modified transcripts into stress granules and modulates mRNA metabolism.
Zhao Z, Qing Y, Dong L, Han L, Wu D, Li Y, Li W, Xue J, Zhou K, Sun M, Tan B, Chen Z, Shen C, Gao L, Small A, Wang K, Leung K, Zhang Z, Qin X, Deng X, Xia Q, Su R, Chen J. Zhao Z, et al. Among authors: xia q. Cell. 2023 Jul 20;186(15):3208-3226.e27. doi: 10.1016/j.cell.2023.05.047. Epub 2023 Jun 27. Cell. 2023. PMID: 37379838
Although m(7)G-cap is essential for pre-mRNA processing and protein synthesis, the exact role of mRNA internal m(7)G modification remains elusive. Here, we report that mRNA internal m(7)G is selectively recognized by Quaking proteins (QKIs). By transcriptome- …
Although m(7)G-cap is essential for pre-mRNA processing and protein synthesis, the exact role of mRNA internal m(7)G modificat …
The essential roles of m(6)A RNA modification to stimulate ENO1-dependent glycolysis and tumorigenesis in lung adenocarcinoma.
Ma L, Xue X, Zhang X, Yu K, Xu X, Tian X, Miao Y, Meng F, Liu X, Guo S, Qiu S, Wang Y, Cui J, Guo W, Li Y, Xia J, Yu Y, Wang J. Ma L, et al. Among authors: xia j. J Exp Clin Cancer Res. 2022 Jan 25;41(1):36. doi: 10.1186/s13046-021-02200-5. J Exp Clin Cancer Res. 2022. PMID: 35078505 Free PMC article.
However, the roles of m(6)A modification in LUAD tumorigenesis is unknown. METHODS: Global m(6)A levels and expressions of m(6)A writers, erasers and readers were evaluated by RNA methylation assay, dot blot, immunoblotting, immunohistochemistry and ELISA in …
However, the roles of m(6)A modification in LUAD tumorigenesis is unknown. METHODS: Global m(6)A levels and expressions of …
N6-Methyladenosine co-transcriptionally directs the demethylation of histone H3K9me2.
Li Y, Xia L, Tan K, Ye X, Zuo Z, Li M, Xiao R, Wang Z, Liu X, Deng M, Cui J, Yang M, Luo Q, Liu S, Cao X, Zhu H, Liu T, Hu J, Shi J, Xiao S, Xia L. Li Y, et al. Among authors: xia l. Nat Genet. 2020 Sep;52(9):870-877. doi: 10.1038/s41588-020-0677-3. Epub 2020 Aug 10. Nat Genet. 2020. PMID: 32778823
We observe a genome-wide correlation between m(6)A and occupancy by the H3K9me2 demethylase KDM3B, and we find that the m(6)A reader YTHDC1 physically interacts with and recruits KDM3B to m(6)A-associated chromatin regions, promoting H3K9me2 demethylation and …
We observe a genome-wide correlation between m(6)A and occupancy by the H3K9me2 demethylase KDM3B, and we find that the m(6)A …
Protective effect of HINT2 on mitochondrial function via repressing MCU complex activation attenuates cardiac microvascular ischemia-reperfusion injury.
Li S, Chen J, Liu M, Chen Y, Wu Y, Li Q, Ma T, Gao J, Xia Y, Fan M, Chen A, Lu D, Su E, Xu F, Chen Z, Qian J, Ge J. Li S, et al. Among authors: xia y. Basic Res Cardiol. 2021 Dec 16;116(1):65. doi: 10.1007/s00395-021-00905-4. Basic Res Cardiol. 2021. PMID: 34914018 Free PMC article.
Mitochondrial calcium uniporter (MCU) complex activation and mitochondrial calcium ([Ca(2+)](m)) overload are underlying mechanisms involved in cardiovascular disease. ...Regaining [Ca(2+)](m) overload by spermine, an MCU agonist, abolished all the protective effect …
Mitochondrial calcium uniporter (MCU) complex activation and mitochondrial calcium ([Ca(2+)](m)) overload are underlying mechanisms i …
Epitranscriptomics in liver disease: Basic concepts and therapeutic potential.
Zhao Z, Meng J, Su R, Zhang J, Chen J, Ma X, Xia Q. Zhao Z, et al. Among authors: xia q. J Hepatol. 2020 Sep;73(3):664-679. doi: 10.1016/j.jhep.2020.04.009. Epub 2020 Apr 21. J Hepatol. 2020. PMID: 32330603 Free article. Review.
The most abundant internal mRNA modification in eukaryotic cells is m(6)A, which exhibits essential roles in physiological processes, such as embryogenesis, carcinogenesis, and neurogenesis. m(6)A is deposited by the m(6)A methyltransferase complex (composed …
The most abundant internal mRNA modification in eukaryotic cells is m(6)A, which exhibits essential roles in physiological processes, …
RNA Modifications Meet Tumors.
Yang Z, Zhang S, Xia T, Fan Y, Shan Y, Zhang K, Xiong J, Gu M, You B. Yang Z, et al. Among authors: xia t. Cancer Manag Res. 2022 Nov 22;14:3223-3243. doi: 10.2147/CMAR.S391067. eCollection 2022. Cancer Manag Res. 2022. PMID: 36444355 Free PMC article. Review.
In this review, we discussed the function of RNA modifications, including N (6)-methyladenine (m(6)A), 5-methylcytosine (m(5)C), N (7)-methyladenosine (m(7)G), N (1)-methyladenosine (m(1)A), pseudouridine (psi), and adenosine-to-inosine (A-to-I), in th …
In this review, we discussed the function of RNA modifications, including N (6)-methyladenine (m(6)A), 5-methylcytosine (m(5)C …
RNA N6-methyladenosine in nonocular and ocular disease.
Wang N, Yao F, Liu D, Jiang H, Xia X, Xiong S. Wang N, et al. Among authors: xia x. J Cell Physiol. 2022 Mar;237(3):1686-1710. doi: 10.1002/jcp.30652. Epub 2021 Dec 15. J Cell Physiol. 2022. PMID: 34913163 Review.
N(6) -methyladenosine (m(6) A), the sixth N methylation of adenylate (A) in RNA, is the most abundant transcriptome modification in eukaryotic messenger RNA (mRNAs). m(6) A modification exists in both coding mRNA and noncoding RNAs, and its functions are controlled …
N(6) -methyladenosine (m(6) A), the sixth N methylation of adenylate (A) in RNA, is the most abundant transcriptome modification in e …
A lncRNA from the FTO locus acts as a suppressor of the m(6)A writer complex and p53 tumor suppression signaling.
Zhang J, Wei J, Sun R, Sheng H, Yin K, Pan Y, Jimenez R, Chen S, Cui XL, Zou Z, Yue Z, Emch MJ, Hawse JR, Wang L, He HH, Xia S, Han B, He C, Huang H. Zhang J, et al. Among authors: xia s. Mol Cell. 2023 Aug 3;83(15):2692-2708.e7. doi: 10.1016/j.molcel.2023.06.024. Epub 2023 Jul 20. Mol Cell. 2023. PMID: 37478845 Free article.
N(6)-methyladenosine (m(6)A) of mRNAs modulated by the METTL3-METTL14-WTAP-RBM15 methyltransferase complex and m(6)A demethylases such as FTO play important roles in regulating mRNA stability, splicing, and translation. ...We further showed that FTO-IT1 directly bin …
N(6)-methyladenosine (m(6)A) of mRNAs modulated by the METTL3-METTL14-WTAP-RBM15 methyltransferase complex and m(6)A demethyla …
Chemical Inhibitors Targeting the Oncogenic m(6)A Modifying Proteins.
Huang Y, Xia W, Dong Z, Yang CG. Huang Y, et al. Among authors: xia w. Acc Chem Res. 2023 Nov 7;56(21):3010-3022. doi: 10.1021/acs.accounts.3c00451. Epub 2023 Oct 27. Acc Chem Res. 2023. PMID: 37889223
However, the significance of m(6)A modification in mRNA had been long neglected until the fat mass and obesity-associated (FTO) enzyme was identified as the first m(6)A demethylase almost 40 years later. ...It is essential to further develop chemical probes and lead …
However, the significance of m(6)A modification in mRNA had been long neglected until the fat mass and obesity-associated (FTO) enzym …
NSUN2-Mediated m(5)C Methylation Impairs Endometrial Receptivity.
Lu J, Zhang M, Liu Z, Guo L, Huang P, Xia W, Li J, Lv J, Cheung HH, Ding C, Li H, Huang B. Lu J, et al. Among authors: xia w. Lab Invest. 2024 Apr;104(4):100327. doi: 10.1016/j.labinv.2024.100327. Epub 2024 Jan 17. Lab Invest. 2024. PMID: 38237738
The overall pattern of m(5)C sites and genes was elucidated through m(5)C-BS-seq, whereas the overall m(5)C levels in different groups were revealed by dot blot assay. ...Our results uncovered a novel intricate regulatory mechanism between NSUN2-mediated m …
The overall pattern of m(5)C sites and genes was elucidated through m(5)C-BS-seq, whereas the overall m(5)C levels in d …
5,419 results