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Inhibitors of histone acetyltransferases KAT6A/B induce senescence and arrest tumour growth.
Baell JB, Leaver DJ, Hermans SJ, Kelly GL, Brennan MS, Downer NL, Nguyen N, Wichmann J, McRae HM, Yang Y, Cleary B, Lagiakos HR, Mieruszynski S, Pacini G, Vanyai HK, Bergamasco MI, May RE, Davey BK, Morgan KJ, Sealey AJ, Wang B, Zamudio N, Wilcox S, Garnham AL, Sheikh BN, Aubrey BJ, Doggett K, Chung MC, de Silva M, Bentley J, Pilling P, Hattarki M, Dolezal O, Dennis ML, Falk H, Ren B, Charman SA, White KL, Rautela J, Newbold A, Hawkins ED, Johnstone RW, Huntington ND, Peat TS, Heath JK, Strasser A, Parker MW, Smyth GK, Street IP, Monahan BJ, Voss AK, Thomas T. Baell JB, et al. Among authors: bergamasco mi. Nature. 2018 Aug;560(7717):253-257. doi: 10.1038/s41586-018-0387-5. Epub 2018 Aug 1. Nature. 2018. PMID: 30069049
Loss of TAF8 causes TFIID dysfunction and p53-mediated apoptotic neuronal cell death.
El-Saafin F, Bergamasco MI, Chen Y, May RE, Esakky P, Hediyeh-Zadeh S, Dixon M, Wilcox S, Davis MJ, Strasser A, Smyth GK, Thomas T, Voss AK. El-Saafin F, et al. Among authors: bergamasco mi. Cell Death Differ. 2022 May;29(5):1013-1027. doi: 10.1038/s41418-022-00982-5. Epub 2022 Mar 31. Cell Death Differ. 2022. PMID: 35361962 Free PMC article.
Stem cell plasticity, acetylation of H3K14, and de novo gene activation rely on KAT7.
Kueh AJ, Bergamasco MI, Quaglieri A, Phipson B, Li-Wai-Suen CSN, Lönnstedt IM, Hu Y, Feng ZP, Woodruff C, May RE, Wilcox S, Garnham AL, Snyder MP, Smyth GK, Speed TP, Thomas T, Voss AK. Kueh AJ, et al. Among authors: bergamasco mi. Cell Rep. 2023 Jan 31;42(1):111980. doi: 10.1016/j.celrep.2022.111980. Epub 2023 Jan 14. Cell Rep. 2023. PMID: 36641753 Free article.
The histone acetyltransferase KAT6B is required for hematopoietic stem cell development and function.
Bergamasco MI, Ranathunga N, Abeysekera W, Li-Wai-Suen CSN, Garnham AL, Willis SN, McRae HM, Yang Y, D'Amico A, Di Rago L, Wilcox S, Nutt SL, Alexander WS, Smyth GK, Voss AK, Thomas T. Bergamasco MI, et al. Stem Cell Reports. 2024 Apr 9;19(4):469-485. doi: 10.1016/j.stemcr.2024.02.005. Epub 2024 Mar 21. Stem Cell Reports. 2024. PMID: 38518784 Free PMC article.