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Page 1
ISRIB Blunts the Integrated Stress Response by Allosterically Antagonising the Inhibitory Effect of Phosphorylated eIF2 on eIF2B.
Mol Cell. 2021 Jan 7;81(1):88-103.e6. doi: 10.1016/j.molcel.2020.10.031. Epub 2020 Nov 20.
Mol Cell. 2021.
PMID: 33220178
Free PMC article.
AMPylation and Endoplasmic Reticulum Protein Folding Homeostasis.
Perera LA, Ron D.
Perera LA, et al.
Cold Spring Harb Perspect Biol. 2023 Mar 1;15(3):a041265. doi: 10.1101/cshperspect.a041265.
Cold Spring Harb Perspect Biol. 2023.
PMID: 36041787
Review.
Item in Clipboard
Structures of a deAMPylation complex rationalise the switch between antagonistic catalytic activities of FICD.
Perera LA, Preissler S, Zaccai NR, Prévost S, Devos JM, Haertlein M, Ron D.
Perera LA, et al.
Nat Commun. 2021 Aug 18;12(1):5004. doi: 10.1038/s41467-021-25076-7.
Nat Commun. 2021.
PMID: 34408154
Free PMC article.
Item in Clipboard
Calcium depletion challenges endoplasmic reticulum proteostasis by destabilising BiP-substrate complexes.
Preissler S, Rato C, Yan Y, Perera LA, Czako A, Ron D.
Preissler S, et al. Among authors: perera la.
Elife. 2020 Dec 9;9:e62601. doi: 10.7554/eLife.62601.
Elife. 2020.
PMID: 33295873
Free PMC article.
Item in Clipboard
Infancy-onset diabetes caused by de-regulated AMPylation of the human endoplasmic reticulum chaperone BiP.
Perera LA, Hattersley AT, Harding HP, Wakeling MN, Flanagan SE, Mohsina I, Raza J, Gardham A, Ron D, De Franco E.
Perera LA, et al.
EMBO Mol Med. 2023 Mar 8;15(3):e16491. doi: 10.15252/emmm.202216491. Epub 2023 Jan 27.
EMBO Mol Med. 2023.
PMID: 36704923
Free PMC article.
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An oligomeric state-dependent switch in the ER enzyme FICD regulates AMPylation and deAMPylation of BiP.
Perera LA, Rato C, Yan Y, Neidhardt L, McLaughlin SH, Read RJ, Preissler S, Ron D.
Perera LA, et al.
EMBO J. 2019 Oct 4;38(21):e102177. doi: 10.15252/embj.2019102177. Epub 2019 Sep 18.
EMBO J. 2019.
PMID: 31531998
Free PMC article.
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