Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1957 1
1972 1
1974 2
1975 3
1976 1
1977 3
1978 1
1979 2
1982 2
1983 3
1984 1
1985 3
1986 2
1988 3
1989 3
1990 4
1991 1
1992 3
1993 8
1994 6
1995 3
1996 9
1997 16
1998 10
1999 16
2000 24
2001 25
2002 21
2003 26
2004 37
2005 29
2006 42
2007 48
2008 65
2009 57
2010 81
2011 73
2012 101
2013 94
2014 104
2015 154
2016 165
2017 182
2018 217
2019 215
2020 246
2021 306
2022 350
2023 368
2024 176

Text availability

Article attribute

Article type

Publication date

Search Results

2,971 results

Results by year

Filters applied: . Clear all
Page 1
m(6)A mRNA methylation controls T cell homeostasis by targeting the IL-7/STAT5/SOCS pathways.
Li HB, Tong J, Zhu S, Batista PJ, Duffy EE, Zhao J, Bailis W, Cao G, Kroehling L, Chen Y, Wang G, Broughton JP, Chen YG, Kluger Y, Simon MD, Chang HY, Yin Z, Flavell RA. Li HB, et al. Among authors: tong j. Nature. 2017 Aug 17;548(7667):338-342. doi: 10.1038/nature23450. Epub 2017 Aug 9. Nature. 2017. PMID: 28792938 Free PMC article.
N(6)-methyladenosine (m(6)A) is the most common and abundant messenger RNA modification, modulated by 'writers', 'erasers' and 'readers' of this mark. In vitro data have shown that m(6)A influences all fundamental aspects of mRNA metabolism, mainly mRNA stability, t …
N(6)-methyladenosine (m(6)A) is the most common and abundant messenger RNA modification, modulated by 'writers', 'erasers' and 'reade …
ALKBH5 is a mammalian RNA demethylase that impacts RNA metabolism and mouse fertility.
Zheng G, Dahl JA, Niu Y, Fedorcsak P, Huang CM, Li CJ, Vågbø CB, Shi Y, Wang WL, Song SH, Lu Z, Bosmans RP, Dai Q, Hao YJ, Yang X, Zhao WM, Tong WM, Wang XJ, Bogdan F, Furu K, Fu Y, Jia G, Zhao X, Liu J, Krokan HE, Klungland A, Yang YG, He C. Zheng G, et al. Among authors: tong wm. Mol Cell. 2013 Jan 10;49(1):18-29. doi: 10.1016/j.molcel.2012.10.015. Epub 2012 Nov 21. Mol Cell. 2013. PMID: 23177736 Free PMC article.
N(6)-methyladenosine (m(6)A) is the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes. ...The discovery of this RNA demethylase strongly suggests that the reversible m(6)A modification has fundamental and broad functions in mammalian …
N(6)-methyladenosine (m(6)A) is the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes. ...The discove …
Mettl3-/Mettl14-mediated mRNA N6-methyladenosine modulates murine spermatogenesis.
Lin Z, Hsu PJ, Xing X, Fang J, Lu Z, Zou Q, Zhang KJ, Zhang X, Zhou Y, Zhang T, Zhang Y, Song W, Jia G, Yang X, He C, Tong MH. Lin Z, et al. Among authors: tong mh. Cell Res. 2017 Oct;27(10):1216-1230. doi: 10.1038/cr.2017.117. Epub 2017 Sep 15. Cell Res. 2017. PMID: 28914256 Free PMC article.
We present comprehensive m(6)A mRNA methylomes of mouse spermatogenic cells from five developmental stages: undifferentiated spermatogonia, type A(1) spermatogonia, preleptotene spermatocytes, pachytene/diplotene spermatocytes, and round spermatids. Germ cell-specific inac …
We present comprehensive m(6)A mRNA methylomes of mouse spermatogenic cells from five developmental stages: undifferentiated spermato …
Pooled CRISPR screening identifies m(6)A as a positive regulator of macrophage activation.
Tong J, Wang X, Liu Y, Ren X, Wang A, Chen Z, Yao J, Mao K, Liu T, Meng FL, Pan W, Zou Q, Liu J, Zhou Y, Xia Q, Flavell RA, Zhu S, Li HB. Tong J, et al. Sci Adv. 2021 Apr 28;7(18):eabd4742. doi: 10.1126/sciadv.abd4742. Print 2021 Apr. Sci Adv. 2021. PMID: 33910903 Free PMC article.
m(6)A RNA modification is implicated in multiple cellular responses. ...Our findings demonstrate a previously unknown role for METTL3-mediated m(6)A modification in innate immune responses and implicate the m(6)A machinery as a potential cancer immunotherapy …
m(6)A RNA modification is implicated in multiple cellular responses. ...Our findings demonstrate a previously unknown role for METTL3 …
METTL3 regulates m(6)A methylation of PTCH1 and GLI2 in Sonic hedgehog signaling to promote tumor progression in SHH-medulloblastoma.
Zhang ZW, Teng X, Zhao F, Ma C, Zhang J, Xiao LF, Wang Y, Chang M, Tian Y, Li C, Zhang Z, Song S, Tong WM, Liu P, Niu Y. Zhang ZW, et al. Among authors: tong wm. Cell Rep. 2022 Oct 25;41(4):111530. doi: 10.1016/j.celrep.2022.111530. Cell Rep. 2022. PMID: 36288719 Free article.
Here we investigate whether dysregulated m(6)A methylation contributes to tumorigenesis of SHH-MB. We show that high expression of m(6)A methyltransferase METTL3 associates with worse survival in the patients with SHH-MB. ...Collectively, this study shows a critical …
Here we investigate whether dysregulated m(6)A methylation contributes to tumorigenesis of SHH-MB. We show that high expression of …
Mild-to-Moderate Kidney Dysfunction and Cardiovascular Disease: Observational and Mendelian Randomization Analyses.
Gaziano L, Sun L, Arnold M, Bell S, Cho K, Kaptoge SK, Song RJ, Burgess S, Posner DC, Mosconi K, Robinson-Cohen C, Mason AM, Bolton TR, Tao R, Allara E, Schubert P, Chen L, Staley JR, Staplin N, Altay S, Amiano P, Arndt V, Ärnlöv J, Barr ELM, Björkelund C, Boer JMA, Brenner H, Casiglia E, Chiodini P, Cooper JA, Coresh J, Cushman M, Dankner R, Davidson KW, de Jongh RT, Donfrancesco C, Engström G, Freisling H, de la Cámara AG, Gudnason V, Hankey GJ, Hansson PO, Heath AK, Hoorn EJ, Imano H, Jassal SK, Kaaks R, Katzke V, Kauhanen J, Kiechl S, Koenig W, Kronmal RA, Kyrø C, Lawlor DA, Ljungberg B, MacDonald C, Masala G, Meisinger C, Melander O, Moreno Iribas C, Ninomiya T, Nitsch D, Nordestgaard BG, Onland-Moret C, Palmieri L, Petrova D, Garcia JRQ, Rosengren A, Sacerdote C, Sakurai M, Santiuste C, Schulze MB, Sieri S, Sundström J, Tikhonoff V, Tjønneland A, Tong T, Tumino R, Tzoulaki I, van der Schouw YT, Monique Verschuren WM, Völzke H, Wallace RB, Wannamethee SG, Weiderpass E, Willeit P, Woodward M, Yamagishi K, Zamora-Ros R, Akwo EA, Pyarajan S, Gagnon DR, Tsao PS, Muralidhar S, Edwards TL, Damrauer SM, Joseph J, Pennells L, Wilson PWF, Harrison S, Gaziano TA, Inouye M, Baige… See abstract for full author list ➔ Gaziano L, et al. Among authors: tong t. Circulation. 2022 Nov 15;146(20):1507-1517. doi: 10.1161/CIRCULATIONAHA.122.060700. Epub 2022 Oct 31. Circulation. 2022. PMID: 36314129 Free PMC article.
RESULTS: There were U-shaped observational associations of creatinine-based eGFR with CHD and stroke, with higher risk in participants with eGFR values <60 or >105 mL.min(-1).1.73 m(-2), compared with those with eGFR between 60 and 105 mL.min(-1).1.73 m(-2). M …
RESULTS: There were U-shaped observational associations of creatinine-based eGFR with CHD and stroke, with higher risk in participants with …
ALKBH5 suppresses malignancy of hepatocellular carcinoma via m(6)A-guided epigenetic inhibition of LYPD1.
Chen Y, Zhao Y, Chen J, Peng C, Zhang Y, Tong R, Cheng Q, Yang B, Feng X, Lu Y, Xie H, Zhou L, Wu J, Zheng S. Chen Y, et al. Among authors: tong r. Mol Cancer. 2020 Aug 10;19(1):123. doi: 10.1186/s12943-020-01239-w. Mol Cancer. 2020. PMID: 32772918 Free PMC article.
Functionally, ALKBH5 suppressed the proliferation and invasion capabilities of HCC cells in vitro and in vivo. Mechanistically, ALKBH5-mediated m(6)A demethylation led to a post-transcriptional inhibition of LY6/PLAUR Domain Containing 1 (LYPD1), which could be recognized …
Functionally, ALKBH5 suppressed the proliferation and invasion capabilities of HCC cells in vitro and in vivo. Mechanistically, ALKBH5-media …
CD98hc is a target for brain delivery of biotherapeutics.
Chew KS, Wells RC, Moshkforoush A, Chan D, Lechtenberg KJ, Tran HL, Chow J, Kim DJ, Robles-Colmenares Y, Srivastava DB, Tong RK, Tong M, Xa K, Yang A, Zhou Y, Akkapeddi P, Annamalai L, Bajc K, Blanchette M, Cherf GM, Earr TK, Gill A, Huynh D, Joy D, Knight KN, Lac D, Leung AW, Lexa KW, Liau NPD, Becerra I, Malfavon M, McInnes J, Nguyen HN, Lozano EI, Pizzo ME, Roche E, Sacayon P, Calvert MEK, Daneman R, Dennis MS, Duque J, Gadkar K, Lewcock JW, Mahon CS, Meisner R, Solanoy H, Thorne RG, Watts RJ, Zuchero YJY, Kariolis MS. Chew KS, et al. Among authors: tong m, tong rk. Nat Commun. 2023 Aug 19;14(1):5053. doi: 10.1038/s41467-023-40681-4. Nat Commun. 2023. PMID: 37598178 Free PMC article.
Tailored Apoptotic Vesicle Delivery Platform for Inflammatory Regulation and Tissue Repair to Ameliorate Ischemic Stroke.
You Y, Xu J, Liu Y, Li H, Xie L, Ma C, Sun Y, Tong S, Liang K, Zhou S, Ma F, Song Q, Xiao W, Fu K, Dai C, Li S, Lei J, Mei Q, Gao X, Chen J. You Y, et al. Among authors: tong s. ACS Nano. 2023 May 9;17(9):8646-8662. doi: 10.1021/acsnano.3c01497. Epub 2023 Apr 26. ACS Nano. 2023. PMID: 37099675
Matrix metalloproteinase activatable cell-penetrating peptide (MAP), a microenvironment-responsive targeting peptide, was modified on the surface of ApoVs to obtain the MAP-functionalized alpha-M-loaded ApoVs. Such engineered ApoVs targeted the injured ischemic brain after …
Matrix metalloproteinase activatable cell-penetrating peptide (MAP), a microenvironment-responsive targeting peptide, was modified on the su …
m(6)A mRNA modification regulates mammalian spermatogenesis.
Lin Z, Tong MH. Lin Z, et al. Among authors: tong mh. Biochim Biophys Acta Gene Regul Mech. 2019 Mar;1862(3):403-411. doi: 10.1016/j.bbagrm.2018.10.016. Epub 2018 Nov 2. Biochim Biophys Acta Gene Regul Mech. 2019. PMID: 30391644 Review.
Mammalian spermatogenesis is a highly specialized differentiation process involving precise regulatory mechanisms at the transcriptional, posttranscriptional, and translational levels. Emerging evidence has shown that N(6)-methyladenosine (m(6)A), an epitranscriptomic regu …
Mammalian spermatogenesis is a highly specialized differentiation process involving precise regulatory mechanisms at the transcriptional, po …
2,971 results