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Page 1
Inverse Drug Discovery identifies weak electrophiles affording protein conjugates.
Curr Opin Chem Biol. 2022 Apr;67:102113. doi: 10.1016/j.cbpa.2021.102113. Epub 2022 Jan 20.
Curr Opin Chem Biol. 2022.
PMID: 35065430
Free PMC article.
Review.
Metabolically Activated Proteostasis Regulators Protect against Glutamate Toxicity by Activating NRF2.
Rosarda JD, Baron KR, Nutsch K, Kline GM, Stanton C, Kelly JW, Bollong MJ, Wiseman RL.
Rosarda JD, et al. Among authors: kline gm.
ACS Chem Biol. 2021 Dec 17;16(12):2852-2863. doi: 10.1021/acschembio.1c00810. Epub 2021 Nov 19.
ACS Chem Biol. 2021.
PMID: 34797633
Free PMC article.
Item in Clipboard
Divergent Proteome Reactivity Influences Arm-Selective Activation of Pharmacological Endoplasmic Reticulum Proteostasis Regulators.
Kline GM, Paxman RJ, Lin CY, Madrazo N, Grandjean JM, Lee K, Nugroho K, Powers ET, Wiseman RL, Kelly JW.
Kline GM, et al.
bioRxiv [Preprint]. 2023 Jan 17:2023.01.16.524237. doi: 10.1101/2023.01.16.524237.
bioRxiv. 2023.
Update in:
ACS Chem Biol. 2023 Aug 18;18(8):1719-1729. doi: 10.1021/acschembio.3c00042.
PMID: 36712115
Free PMC article.
Updated.
Preprint.
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The conformational landscape of human transthyretin revealed by cryo-EM.
Basanta B, Nugroho K, Yan NL, Kline GM, Powers ET, Tsai FJ, Wu M, Hansel-Harris A, Chen JS, Forli S, Kelly JW, Lander GC.
Basanta B, et al. Among authors: kline gm.
bioRxiv [Preprint]. 2024 Jan 23:2024.01.23.576879. doi: 10.1101/2024.01.23.576879.
bioRxiv. 2024.
PMID: 38328110
Free PMC article.
Preprint.
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Divergent Proteome Reactivity Influences Arm-Selective Activation of the Unfolded Protein Response by Pharmacological Endoplasmic Reticulum Proteostasis Regulators.
Kline GM, Paxman RJ, Lin CY, Madrazo N, Yoon L, Grandjean JMD, Lee K, Nugroho K, Powers ET, Wiseman RL, Kelly JW.
Kline GM, et al.
ACS Chem Biol. 2023 Aug 18;18(8):1719-1729. doi: 10.1021/acschembio.3c00042. Epub 2023 Jul 31.
ACS Chem Biol. 2023.
PMID: 37523656
Free PMC article.
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Characterising diflunisal as a transthyretin kinetic stabilizer at relevant concentrations in human plasma using subunit exchange.
Tsai FJ, Nelson LT, Kline GM, Jäger M, Berk JL, Sekijima Y, Powers ET, Kelly JW.
Tsai FJ, et al. Among authors: kline gm.
Amyloid. 2023 Jun;30(2):220-224. doi: 10.1080/13506129.2022.2148094. Epub 2022 Nov 29.
Amyloid. 2023.
PMID: 36444793
Free PMC article.
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