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An African-Specific Variant of TP53 Reveals PADI4 as a Regulator of p53-Mediated Tumor Suppression.
Indeglia A, Leung JC, Miller SA, Leu JI, Dougherty JF, Clarke NL, Kirven NA, Shao C, Ke L, Lovell S, Barnoud T, Lu DY, Lin C, Kannan T, Battaile KP, Yang THL, Batista Oliva I, Claiborne DT, Vogel P, Liu L, Liu Q, Nefedova Y, Cassel J, Auslander N, Kossenkov AV, Karanicolas J, Murphy ME. Indeglia A, et al. Cancer Discov. 2023 Jul 7;13(7):1696-1719. doi: 10.1158/2159-8290.CD-22-1315. Cancer Discov. 2023. PMID: 37140445 Free PMC article.
p53 restoration in small cell lung cancer identifies a latent cyclophilin-dependent necrosis mechanism.
Acosta J, Li Q, Freeburg NF, Murali N, Indeglia A, Grothusen GP, Cicchini M, Mai H, Gladstein AC, Adler KM, Doerig KR, Li J, Ruiz-Torres M, Manning KL, Stanger BZ, Busino L, Murphy M, Wan L, Feldser DM. Acosta J, et al. Among authors: indeglia a. Nat Commun. 2023 Jul 21;14(1):4403. doi: 10.1038/s41467-023-40161-9. Nat Commun. 2023. PMID: 37479684 Free PMC article.
Common activities and predictive gene signature identified for genetic hypomorphs of TP53.
Leung JC, Leu JI, Indeglia A, Kannan T, Clarke NL, Kirven NA, Dweep H, Garlick D, Barnoud T, Kossenkov AV, George DL, Murphy ME. Leung JC, et al. Among authors: indeglia a. Proc Natl Acad Sci U S A. 2023 Feb 14;120(7):e2212940120. doi: 10.1073/pnas.2212940120. Epub 2023 Feb 7. Proc Natl Acad Sci U S A. 2023. PMID: 36749725 Free PMC article.
A Novel Inhibitor of HSP70 Induces Mitochondrial Toxicity and Immune Cell Recruitment in Tumors.
Barnoud T, Leung JC, Leu JI, Basu S, Poli ANR, Parris JLD, Indeglia A, Martynyuk T, Good M, Gnanapradeepan K, Sanseviero E, Moeller R, Tang HY, Cassel J, Kossenkov AV, Liu Q, Speicher DW, Gabrilovich DI, Salvino JM, George DL, Murphy ME. Barnoud T, et al. Among authors: indeglia a. Cancer Res. 2020 Dec 1;80(23):5270-5281. doi: 10.1158/0008-5472.CAN-20-0397. Epub 2020 Oct 6. Cancer Res. 2020. PMID: 33023943 Free PMC article.