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Architectural basis for cylindrical self-assembly governing Plk4-mediated centriole duplication in human cells.
Il Ahn J, Zhang L, Ravishankar H, Fan L, Kirsch K, Zeng Y, Meng L, Park JE, Yun HY, Ghirlando R, Ma B, Ball D, Ku B, Nussinov R, Schmit JD, Heinz WF, Kim SJ, Karpova T, Wang YX, Lee KS. Il Ahn J, et al. Among authors: kirsch k. Commun Biol. 2023 Jul 11;6(1):712. doi: 10.1038/s42003-023-05067-8. Commun Biol. 2023. PMID: 37433832 Free PMC article.
MAP Kinase-Mediated Activation of RSK1 and MK2 Substrate Kinases.
Sok P, Gógl G, Kumar GS, Alexa A, Singh N, Kirsch K, Sebő A, Drahos L, Gáspári Z, Peti W, Reményi A. Sok P, et al. Among authors: kirsch k. Structure. 2020 Oct 6;28(10):1101-1113.e5. doi: 10.1016/j.str.2020.06.007. Epub 2020 Jul 9. Structure. 2020. PMID: 32649858 Free PMC article.
Author Correction: Architectural basis for cylindrical self-assembly governing Plk4-mediated centriole duplication in human cells.
Il Ahn J, Zhang L, Ravishankar H, Fan L, Kirsch K, Zeng Y, Meng L, Park JE, Yun HY, Ghirlando R, Ma B, Ball D, Ku B, Nussinov R, Schmit JD, Heinz WF, Kim SJ, Karpova T, Wang YX, Lee KS. Il Ahn J, et al. Among authors: kirsch k. Commun Biol. 2023 Jul 27;6(1):784. doi: 10.1038/s42003-023-05162-w. Commun Biol. 2023. PMID: 37500946 Free PMC article. No abstract available.
Specific inhibition of an anticancer target, polo-like kinase 1, by allosterically dismantling its mechanism of substrate recognition.
Park JE, Kirsch K, Lee H, Oliva P, Ahn JI, Ravishankar H, Zeng Y, Fox SD, Kirby SA, Badhwar P, Andresson T, Jacobson KA, Lee KS. Park JE, et al. Among authors: kirsch k. Proc Natl Acad Sci U S A. 2023 Aug 29;120(35):e2305037120. doi: 10.1073/pnas.2305037120. Epub 2023 Aug 21. Proc Natl Acad Sci U S A. 2023. PMID: 37603740 Free PMC article.
Structural Optimization and Anticancer Activity of Polo-like Kinase 1 (Plk1) Polo-Box Domain (PBD) Inhibitors and Their Prodrugs.
Park JE, Lee H, Oliva P, Kirsch K, Kim B, Ahn JI, Alverez CN, Gaikwad S, Krausz KW, O'Connor R, Rai G, Simeonov A, Mock BA, Gonzalez FJ, Lee KS, Jacobson KA. Park JE, et al. Among authors: kirsch k. ACS Pharmacol Transl Sci. 2023 Feb 20;6(3):422-446. doi: 10.1021/acsptsci.2c00250. eCollection 2023 Mar 10. ACS Pharmacol Transl Sci. 2023. PMID: 36926457 Free PMC article.