Genomic Analysis of Foxp3 Function in Regulatory T Cells

Gabriel A Dolsten; Yuri Pritykin

doi:10.4049/jimmunol.2200864

Genomic Analysis of Foxp3 Function in Regulatory T Cells

J Immunol. 2023 Apr 1;210(7):880-887. doi: 10.4049/jimmunol.2200864.

Authors

Gabriel A Dolsten^{1

2}, Yuri Pritykin^{1

3}

Affiliations

¹ Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ.
² Quantitative and Computational Biology Graduate Program, Princeton University, Princeton, NJ.
³ Department of Computer Science, Princeton University, Princeton, NJ.

Abstract

Regulatory T (Treg) cells are critical for tolerance to self-antigens and for preventing autoimmunity. Foxp3 has been identified as a Treg cell lineage-defining transcription factor controlling Treg cell differentiation and function. In this article, we review the current mechanistic and systemic understanding of Foxp3 function enabled by experimental and computational advances in high-throughput genomics.

Publication types

Review
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Cell Differentiation / genetics
Forkhead Transcription Factors / metabolism
Gene Expression Regulation*
Genomics
T-Lymphocytes, Regulatory*
Transcription Factors / genetics

Substances

Transcription Factors
Forkhead Transcription Factors

Grants and funding

DP2 AI171161/AI/NIAID NIH HHS/United States