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Activating point mutations in the MET kinase domain represent a unique molecular subset of lung cancer and other malignancies targetable with MET inhibitors.
Pecci F, Nakazawa S, Ricciuti B, Harada G, Lee JK, Alessi JV, Barrichello A, Vaz VR, Lamberti G, Di Federico A, Gandhi MM, Gazgalis D, Feng WW, Jiang J, Baldacci S, Locquet MA, Gottlieb FH, Chen MF, Lee E, Haradon D, Smokovich A, Voligny E, Nguyen T, Goel VK, Zimmerman Z, Atwal S, Wang X, Bahcall M, Heist RS, Iqbal S, Gandhi N, Elliott A, Vanderwalde AM, Ma PC, Halmos B, Liu SV, Che J, Schrock AB, Drilon A, Janne PA, Awad MM. Pecci F, et al. Among authors: gazgalis d. Cancer Discov. 2024 Apr 3. doi: 10.1158/2159-8290.CD-23-1217. Online ahead of print. Cancer Discov. 2024. PMID: 38564707
Molecular determinants of Kv7.1/KCNE1 channel inhibition by amitriptyline.
Villatoro-Gómez K, Pacheco-Rojas DO, Moreno-Galindo EG, Navarro-Polanco RA, Tristani-Firouzi M, Gazgalis D, Cui M, Sánchez-Chapula JA, Ferrer T. Villatoro-Gómez K, et al. Among authors: gazgalis d. Biochem Pharmacol. 2018 Jun;152:264-271. doi: 10.1016/j.bcp.2018.03.016. Epub 2018 Apr 3. Biochem Pharmacol. 2018. PMID: 29621539
Synthetic Aβ peptides acquire prion-like properties in the brain.
Xiao X, Cali I, Yuan J, Cracco L, Curtiss P, Zeng L, Abouelsaad M, Gazgalis D, Wang GX, Kong Q, Fujioka H, Puoti G, Zou WQ. Xiao X, et al. Among authors: gazgalis d. Oncotarget. 2015 Jan 20;6(2):642-50. doi: 10.18632/oncotarget.2819. Oncotarget. 2015. PMID: 25460507 Free PMC article.
The small molecule GAT1508 activates brain-specific GIRK1/2 channel heteromers and facilitates conditioned fear extinction in rodents.
Xu Y, Cantwell L, Molosh AI, Plant LD, Gazgalis D, Fitz SD, Dustrude ET, Yang Y, Kawano T, Garai S, Noujaim SF, Shekhar A, Logothetis DE, Thakur GA. Xu Y, et al. Among authors: gazgalis d. J Biol Chem. 2020 Mar 13;295(11):3614-3634. doi: 10.1074/jbc.RA119.011527. Epub 2020 Jan 17. J Biol Chem. 2020. PMID: 31953327 Free PMC article.
Comparative Study of Prions in Iatrogenic and Sporadic Creutzfeldt-Jakob Disease.
Xiao X, Yuan J, Qing L, Cali I, Mikol J, Delisle MB, Uro-Coste E, Zeng L, Abouelsaad M, Gazgalis D, Martinez MC, Wang GX, Brown P, Ironside JW, Gambetti P, Kong Q, Zou WQ. Xiao X, et al. Among authors: gazgalis d. J Clin Cell Immunol. 2014 Aug;5(4):240. doi: 10.4172/2155-9899.1000240. J Clin Cell Immunol. 2014. PMID: 25419482 Free PMC article.