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Formate overflow drives toxic folate trapping in MTHFD1 inhibited cancer cells.
Green AC, Marttila P, Kiweler N, Chalkiadaki C, Wiita E, Cookson V, Lesur A, Eiden K, Bernardin F, Vallin KSA, Borhade S, Long M, Ghahe EK, Jiménez-Alonso JJ, Jemth AS, Loseva O, Mortusewicz O, Meyers M, Viry E, Johansson AI, Hodek O, Homan E, Bonagas N, Ramos L, Sandberg L, Frödin M, Moussay E, Slipicevic A, Letellier E, Paggetti J, Sørensen CS, Helleday T, Henriksson M, Meiser J. Green AC, et al. Among authors: chalkiadaki c. Nat Metab. 2023 Apr;5(4):642-659. doi: 10.1038/s42255-023-00771-5. Epub 2023 Apr 3. Nat Metab. 2023. PMID: 37012496 Free PMC article.
The one-carbon metabolic enzyme MTHFD2 promotes resection and homologous recombination after ionizing radiation.
Marttila P, Bonagas N, Chalkiadaki C, Stigsdotter H, Schelzig K, Shen J, Farhat CM, Hondema A, Albers J, Wiita E, Rasti A, Warpman Berglund U, Slipicevic A, Mortusewicz O, Helleday T. Marttila P, et al. Among authors: chalkiadaki c. Mol Oncol. 2024 Sep;18(9):2179-2195. doi: 10.1002/1878-0261.13645. Epub 2024 Mar 27. Mol Oncol. 2024. PMID: 38533616 Free PMC article.
DNA Damage Estimation after Chronic and Combined Exposure to Endocrine Disruptors: An In Vivo Real-Life Risk Simulation Approach.
Karzi V, Ozcagli E, Tzatzarakis MN, Vakonaki E, Fragkiadoulaki I, Kalliantasi A, Chalkiadaki C, Alegakis A, Stivaktakis P, Karzi A, Makrigiannakis A, Docea AO, Calina D, Tsatsakis A. Karzi V, et al. Among authors: chalkiadaki c. Int J Mol Sci. 2023 Jun 10;24(12):9989. doi: 10.3390/ijms24129989. Int J Mol Sci. 2023. PMID: 37373136 Free PMC article.
In Vivo Estimation of the Biological Effects of Endocrine Disruptors in Rabbits after Combined and Long-Term Exposure: Study Protocol.
Karzi V, Tzatzarakis MN, Alegakis A, Vakonaki E, Fragkiadoulaki I, Kaloudis K, Chalkiadaki C, Apalaki P, Panagiotopoulou M, Kalliantasi A, Kouretas D, Docea AO, Calina D, Tsatsakis A. Karzi V, et al. Among authors: chalkiadaki c. Toxics. 2022 May 12;10(5):246. doi: 10.3390/toxics10050246. Toxics. 2022. PMID: 35622659 Free PMC article.