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Page 1
Formate overflow drives toxic folate trapping in MTHFD1 inhibited cancer cells.
Nat Metab. 2023 Apr;5(4):642-659. doi: 10.1038/s42255-023-00771-5. Epub 2023 Apr 3.
Nat Metab. 2023.
PMID: 37012496
Free PMC article.
Pharmacological targeting of MTHFD2 suppresses acute myeloid leukemia by inducing thymidine depletion and replication stress.
Bonagas N, Gustafsson NMS, Henriksson M, Marttila P, Gustafsson R, Wiita E, Borhade S, Green AC, Vallin KSA, Sarno A, Svensson R, Göktürk C, Pham T, Jemth AS, Loseva O, Cookson V, Kiweler N, Sandberg L, Rasti A, Unterlass JE, Haraldsson M, Andersson Y, Scaletti ER, Bengtsson C, Paulin CBJ, Sanjiv K, Abdurakhmanov E, Pudelko L, Kunz B, Desroses M, Iliev P, Färnegårdh K, Krämer A, Garg N, Michel M, Häggblad S, Jarvius M, Kalderén C, Jensen AB, Almlöf I, Karsten S, Zhang SM, Häggblad M, Eriksson A, Liu J, Glinghammar B, Nekhotiaeva N, Klingegård F, Koolmeister T, Martens U, Llona-Minguez S, Moulson R, Nordström H, Parrow V, Dahllund L, Sjöberg B, Vargas IL, Vo DD, Wannberg J, Knapp S, Krokan HE, Arvidsson PI, Scobie M, Meiser J, Stenmark P, Berglund UW, Homan EJ, Helleday T.
Bonagas N, et al. Among authors: borhade s.
Nat Cancer. 2022 Feb;3(2):156-172. doi: 10.1038/s43018-022-00331-y. Epub 2022 Feb 28.
Nat Cancer. 2022.
PMID: 35228749
Free PMC article.
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NUDT15-mediated hydrolysis limits the efficacy of anti-HCMV drug ganciclovir.
Zhang SM, Rehling D, Jemth AS, Throup A, Landázuri N, Almlöf I, Göttmann M, Valerie NCK, Borhade SR, Wakchaure P, Page BDG, Desroses M, Homan EJ, Scobie M, Rudd SG, Berglund UW, Söderberg-Nauclér C, Stenmark P, Helleday T.
Zhang SM, et al. Among authors: borhade sr.
Cell Chem Biol. 2021 Dec 16;28(12):1693-1702.e6. doi: 10.1016/j.chembiol.2021.06.001. Epub 2021 Jun 29.
Cell Chem Biol. 2021.
PMID: 34192523
Free article.
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Preclinical characterization of acyl sulfonimidamides: potential carboxylic acid bioisosteres with tunable properties.
Borhade SR, Svensson R, Brandt P, Artursson P, Arvidsson PI, Sandström A.
Borhade SR, et al.
ChemMedChem. 2015 Mar;10(3):455-60. doi: 10.1002/cmdc.201402497. Epub 2015 Jan 28.
ChemMedChem. 2015.
PMID: 25630705
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Synthesis of novel aryl and heteroaryl acyl sulfonimidamides via Pd-catalyzed carbonylation using a nongaseous precursor.
Borhade SR, Sandström A, Arvidsson PI.
Borhade SR, et al.
Org Lett. 2013 Mar 1;15(5):1056-9. doi: 10.1021/ol400049m. Epub 2013 Feb 8.
Org Lett. 2013.
PMID: 23394148
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Inhibition of Insulin-Regulated Aminopeptidase (IRAP) by Arylsulfonamides.
Borhade SR, Rosenström U, Sävmarker J, Lundbäck T, Jenmalm-Jensen A, Sigmundsson K, Axelsson H, Svensson F, Konda V, Sköld C, Larhed M, Hallberg M.
Borhade SR, et al.
ChemistryOpen. 2014 Dec;3(6):256-63. doi: 10.1002/open.201402027. Epub 2014 Nov 21.
ChemistryOpen. 2014.
PMID: 25558444
Free PMC article.
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Studies on Pd/NiFe(2)O(4) catalyzed ligand-free Suzuki reaction in aqueous phase: synthesis of biaryls, terphenyls and polyaryls.
Borhade SR, Waghmode SB.
Borhade SR, et al.
Beilstein J Org Chem. 2011 Mar 15;7:310-9. doi: 10.3762/bjoc.7.41.
Beilstein J Org Chem. 2011.
PMID: 21448255
Free PMC article.
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