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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1954 2
1965 2
1967 1
1975 4
1976 1
1977 1
1978 3
1979 4
1980 6
1981 7
1982 11
1983 5
1984 7
1985 10
1986 12
1987 18
1988 20
1989 19
1990 40
1991 34
1992 44
1993 68
1994 68
1995 65
1996 88
1997 95
1998 117
1999 137
2000 163
2001 197
2002 227
2003 258
2004 314
2005 365
2006 368
2007 483
2008 534
2009 646
2010 803
2011 825
2012 912
2013 1099
2014 1335
2015 1530
2016 1723
2017 1786
2018 1933
2019 2147
2020 2492
2021 2728
2022 2747
2023 2765
2024 1328

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27,115 results

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Page 1
R-loop and its functions at the regulatory interfaces between transcription and (epi)genome.
Kim A, Wang GG. Kim A, et al. Biochim Biophys Acta Gene Regul Mech. 2021 Nov-Dec;1864(11-12):194750. doi: 10.1016/j.bbagrm.2021.194750. Epub 2021 Aug 28. Biochim Biophys Acta Gene Regul Mech. 2021. PMID: 34461314 Free PMC article. Review.
R-loop represents a prevalent and specialized chromatin structure critically involved in a wide range of biological processes. ...Cellular "readers" of R-loops are identified, exerting crucial impacts on R-loop homeostasis and gene regulation. ...
R-loop represents a prevalent and specialized chromatin structure critically involved in a wide range of biological processes. ...Cel …
Emerging role for R-loop formation in hepatocellular carcinoma.
Baek H, Park SU, Kim J. Baek H, et al. Among authors: kim j. Genes Genomics. 2023 May;45(5):543-551. doi: 10.1007/s13258-022-01360-8. Epub 2023 Jan 12. Genes Genomics. 2023. PMID: 36635460 Review.
Given that R-loop is natural by-product formed during normal transcription condition, and that several types of cancer have defense mechanism against the genomic instability resulted from R-loop formation, modulating functional implication of proteins involved in th …
Given that R-loop is natural by-product formed during normal transcription condition, and that several types of cancer have defense m …
Clinical and Mechanistic Implications of R-Loops in Human Leukemias.
Lee SY, Miller KM, Kim JJ. Lee SY, et al. Among authors: kim jj. Int J Mol Sci. 2023 Mar 22;24(6):5966. doi: 10.3390/ijms24065966. Int J Mol Sci. 2023. PMID: 36983041 Free PMC article. Review.
In this review, we discuss the current understanding of aberrant R-loop formation and how it influences genomic instability and leukemia development. We also consider the possibility of R-loops as therapeutic targets for cancer treatment....
In this review, we discuss the current understanding of aberrant R-loop formation and how it influences genomic instability and leuke …
Robot-assisted retroperitoneal lymph node dissection: a systematic review of perioperative outcomes.
Garg H, Mansour AM, Psutka SP, Kim SP, Porter J, Gaspard CS, Dursun F, Pruthi DK, Wang H, Kaushik D. Garg H, et al. Among authors: kim sp. BJU Int. 2023 Jul;132(1):9-30. doi: 10.1111/bju.15986. Epub 2023 Mar 9. BJU Int. 2023. PMID: 36754376 Review.
Of 459 patients in the single-arm studies, 271 underwent primary R-RPLND and 188 underwent post-chemotherapy R-RPLND. For primary R-RPLND, the operative time ranged from 175 to 540 min and the major complication rate was 4.1%. ...The conversion rate to open s …
Of 459 patients in the single-arm studies, 271 underwent primary R-RPLND and 188 underwent post-chemotherapy R-RPLND. For prim …
Gallic acid-mitochondria targeting sequence-H(3)R(9) induces mitochondria-targeted cytoprotection.
Bae Y, Kim GY, Jessa F, Ko KS, Han J. Bae Y, et al. Among authors: kim gy. Korean J Physiol Pharmacol. 2022 Jan 1;26(1):15-24. doi: 10.4196/kjpp.2022.26.1.15. Korean J Physiol Pharmacol. 2022. PMID: 34965992 Free PMC article.
In viability assays, GA-MTS-H(3)R(9) showed a better rescue action compared to that of MTS-H(3)R(9). ...GA-MTS-H(3)R(9) showed a very increased cytoprotective effect against anticancer activity compared to that of MTS-H(3)R(9). ...
In viability assays, GA-MTS-H(3)R(9) showed a better rescue action compared to that of MTS-H(3)R(9). ...GA-MTS-H(3)R(9) …
Direct visualization of replication and R-loop collision using single-molecule imaging.
Kim S, Shin WH, Kang Y, Kim H, Lee JY. Kim S, et al. Among authors: kim h. Nucleic Acids Res. 2024 Jan 11;52(1):259-273. doi: 10.1093/nar/gkad1101. Nucleic Acids Res. 2024. PMID: 37994723 Free PMC article.
R-loops are three-stranded nucleic acid structures that can cause replication stress by blocking replication fork progression. However, the detailed mechanism underlying the collision of DNA replication forks and R-loops remains elusive. To investigate how R- …
R-loops are three-stranded nucleic acid structures that can cause replication stress by blocking replication fork progression. Howeve …
P2Y(2)R-mediated transactivation of VEGFR2 through Src phosphorylation is associated with ESM-1 overexpression in radiotherapy-resistant-triple negative breast cancer cells.
Jin H, Ko YS, Yun SP, Park SW, Kim HJ. Jin H, et al. Among authors: kim hj. Int J Oncol. 2023 Jun;62(6):73. doi: 10.3892/ijo.2023.5521. Epub 2023 May 11. Int J Oncol. 2023. PMID: 37165911
In addition, ESM-1 is involved in an increased proliferation and invasion of RT-R-TNBC cells compared with TNBC cells. It was further identified that, in RT-R-TNBC cells, P2Y(2) purinergic receptor (P2Y(2)R)-mediated activation of p21-activated kinase 1 (PAK1 …
In addition, ESM-1 is involved in an increased proliferation and invasion of RT-R-TNBC cells compared with TNBC cells. It was further …
Thrap3 promotes R-loop resolution via interaction with methylated DDX5.
Kang HJ, Eom HJ, Kim H, Myung K, Kwon HM, Choi JH. Kang HJ, et al. Among authors: kim h. Exp Mol Med. 2021 Oct;53(10):1602-1611. doi: 10.1038/s12276-021-00689-6. Epub 2021 Oct 25. Exp Mol Med. 2021. PMID: 34697388 Free PMC article.
Although these structures have been studied, many aspects of R-loop biology and R-loop-mediated genome instability remain unclear. Here, we demonstrate that thyroid hormone receptor-associated protein 3 (Thrap3) plays a critical role in regulating R-loop reso …
Although these structures have been studied, many aspects of R-loop biology and R-loop-mediated genome instability remain uncl …
Unveiling the Differences in Signaling and Regulatory Mechanisms between Dopamine D2 and D3 Receptors and Their Impact on Behavioral Sensitization.
Kim KM. Kim KM. Int J Mol Sci. 2023 Apr 4;24(7):6742. doi: 10.3390/ijms24076742. Int J Mol Sci. 2023. PMID: 37047716 Free PMC article. Review.
Dopamine receptors are classified into five subtypes, with D(2)R and D(3)R playing a crucial role in regulating mood, motivation, reward, and movement. ...Overall, a series of biochemical settings more closely related to D(3)R could be linked to D(3)R- …
Dopamine receptors are classified into five subtypes, with D(2)R and D(3)R playing a crucial role in regulating mood, motivati …
Therapeutic strategies, including allogeneic stem cell transplantation, to overcome relapsed/refractory adult T-cell acute lymphoblastic leukemia.
Baek DW, Lee JM, Kim J, Cho HJ, Moon JH, Sohn SK. Baek DW, et al. Among authors: kim j. Expert Rev Hematol. 2021 Aug;14(8):765-775. doi: 10.1080/17474086.2021.1960817. Epub 2021 Aug 9. Expert Rev Hematol. 2021. PMID: 34313508 Review.
However, the optimal therapeutic approach to R/R adult T-ALL remains poorly established. AREAS COVERED: At present, cytoreductive therapy followed by allogeneic stem cell transplantation (allo-SCT) is considered to be the most clinically relevant and curative modali …
However, the optimal therapeutic approach to R/R adult T-ALL remains poorly established. AREAS COVERED: At present, cytoreduct …
27,115 results
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