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Page 1
Restoration of DNA repair mitigates genome instability and increases productivity of Chinese hamster ovary cells.
Biotechnol Bioeng. 2022 Mar;119(3):963-982. doi: 10.1002/bit.28016. Epub 2022 Jan 5.
Biotechnol Bioeng. 2022.
PMID: 34953085
Free PMC article.
Comprehensive assessment of host cell protein expression after extended culture and bioreactor production of CHO cell lines.
Hamaker NK, Min L, Lee KH.
Hamaker NK, et al.
Biotechnol Bioeng. 2022 Aug;119(8):2221-2238. doi: 10.1002/bit.28128. Epub 2022 May 16.
Biotechnol Bioeng. 2022.
PMID: 35508759
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High-efficiency and multilocus targeted integration in CHO cells using CRISPR-mediated donor nicking and DNA repair inhibitors.
Hamaker NK, Lee KH.
Hamaker NK, et al.
Biotechnol Bioeng. 2023 Sep;120(9):2419-2440. doi: 10.1002/bit.28393. Epub 2023 Apr 11.
Biotechnol Bioeng. 2023.
PMID: 37039773
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Site-specific Integration Ushers in a New Era of Precise CHO Cell Line Engineering.
Hamaker NK, Lee KH.
Hamaker NK, et al.
Curr Opin Chem Eng. 2018 Dec;22:152-160. doi: 10.1016/j.coche.2018.09.011. Epub 2018 Oct 23.
Curr Opin Chem Eng. 2018.
PMID: 31086757
Free PMC article.
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Comparison of vector elements and process conditions in transient and stable suspension HEK293 platforms using SARS-CoV-2 receptor binding domain as a model protein.
Green EA, Hamaker NK, Lee KH.
Green EA, et al. Among authors: hamaker nk.
BMC Biotechnol. 2023 Mar 7;23(1):7. doi: 10.1186/s12896-023-00777-7.
BMC Biotechnol. 2023.
PMID: 36882740
Free PMC article.
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A Site-Specific Integration Reporter System That Enables Rapid Evaluation of CRISPR/Cas9-Mediated Genome Editing Strategies in CHO Cells.
Hamaker NK, Lee KH.
Hamaker NK, et al.
Biotechnol J. 2020 Aug;15(8):e2000057. doi: 10.1002/biot.202000057. Epub 2020 Jun 21.
Biotechnol J. 2020.
PMID: 32500600
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A temporary immersion plant propagation bioreactor with decoupled gas and liquid flows for enhanced control of gas phase.
Florez SL, Curtis MS, Shaw SE, Hamaker NK, Larsen JS, Curtis WR.
Florez SL, et al. Among authors: hamaker nk.
Biotechnol Prog. 2016 Mar;32(2):337-45. doi: 10.1002/btpr.2221. Epub 2016 Jan 27.
Biotechnol Prog. 2016.
PMID: 26698639
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