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Spatially Resolved Transcriptomics Deconvolutes Prognostic Histological Subgroups in Patients with Colorectal Cancer and Synchronous Liver Metastases.
Wood CS, Pennel KAF, Leslie H, Legrini A, Cameron AJ, Melissourgou-Syka L, Quinn JA, van Wyk HC, Hay J, Roseweir AK, Nixon C, Roxburgh CSD, McMillan DC, Biankin AV, Sansom OJ, Horgan PG, Edwards J, Steele CW, Jamieson NB. Wood CS, et al. Among authors: pennel kaf. Cancer Res. 2023 Apr 14;83(8):1329-1344. doi: 10.1158/0008-5472.CAN-22-2794. Cancer Res. 2023. PMID: 37057593 Free PMC article.
JAK/STAT3 represents a therapeutic target for colorectal cancer patients with stromal-rich tumors.
Pennel KAF, Hatthakarnkul P, Wood CS, Lian GY, Al-Badran SSF, Quinn JA, Legrini A, Inthagard J, Alexander PG, van Wyk H, Kurniawan A, Hashmi U, Gillespie MA, Mills M, Ammar A, Hay J, Andersen D, Nixon C, Rebus S, Chang DK, Kelly C, Harkin A, Graham J, Church D, Tomlinson I, Saunders M, Iveson T, Lannagan TRM, Jackstadt R, Maka N, Horgan PG, Roxburgh CSD, Sansom OJ, McMillan DC, Steele CW, Jamieson NB, Park JH, Roseweir AK, Edwards J. Pennel KAF, et al. J Exp Clin Cancer Res. 2024 Mar 1;43(1):64. doi: 10.1186/s13046-024-02958-4. J Exp Clin Cancer Res. 2024. PMID: 38424636 Free PMC article.
The relationship between the Glasgow Microenvironment Score and markers of epithelial-mesenchymal transition in TNM II-III colorectal cancer.
Alexander PG, Matly AAM, Jirapongwattana N, Pennel KAF, van Wyk HC, McMillan DC, Horgan PG, Roxburgh CSD, Thuwajit C, Roseweir AK, Quinn J, Park JH, Edwards J. Alexander PG, et al. Among authors: pennel kaf. Hum Pathol. 2022 Sep;127:1-11. doi: 10.1016/j.humpath.2022.05.012. Epub 2022 May 25. Hum Pathol. 2022. PMID: 35623467 Free article.
The Glasgow Microenvironment Score associates with prognosis and adjuvant chemotherapy response in colorectal cancer.
Alexander PG, Roseweir AK, Pennel KAF, van Wyk HC, Powell AGMT, McMillan DC, Horgan PG, Kelly C, Hay J, Sansom O, Harkin A, Roxburgh CSD, Graham J, Church DN, Tomlinson I, Saunders M, Iveson TJ, Edwards J, Park JH. Alexander PG, et al. Among authors: pennel kaf. Br J Cancer. 2021 Feb;124(4):786-796. doi: 10.1038/s41416-020-01168-x. Epub 2020 Nov 23. Br J Cancer. 2021. PMID: 33223535 Free PMC article.
Protein expression of S100A2 reveals it association with patient prognosis and immune infiltration profile in colorectal cancer.
Hatthakarnkul P, Ammar A, Pennel KAF, Officer-Jones L, Cusumano S, Quinn JA, Matly AAM, Alexander PG, Hay J, Andersen D, Lynch G, van Wyk HC, Maka N, McMillan DC, Le Quesne J, Thuwajit C, Edwards J. Hatthakarnkul P, et al. Among authors: pennel kaf. J Cancer. 2023 Jun 19;14(10):1837-1847. doi: 10.7150/jca.83910. eCollection 2023. J Cancer. 2023. PMID: 37476187 Free PMC article.
TAK1 expression is associated with increased PD-L1 and decreased cancer-specific survival in microsatellite-stable colorectal cancer.
Galbraith NJ, Quinn JA, Al-Badran SS, Pennel KAF, Hillson LVS, Hatthakarnkul P, McKenzie M, Maka N, Loi L, Frixou M, Steele CW, Roxburgh CS, Horgan PG, McMillan DC, Edwards J. Galbraith NJ, et al. Among authors: pennel kaf. Transl Oncol. 2024 Oct;48:102064. doi: 10.1016/j.tranon.2024.102064. Epub 2024 Jul 27. Transl Oncol. 2024. PMID: 39068768 Free PMC article.