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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2002 11
2003 6
2004 1
2005 1
2006 1
2007 1
2019 1
2021 1
2022 3
2023 2
2024 1

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28 results

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Page 1
Multi-omics analyses reveal ClpP activators disrupt essential mitochondrial pathways in triple-negative breast cancer.
Fennell EMJ, Aponte-Collazo LJ, Pathmasiri W, Rushing BR, Barker NK, Partridge MC, Li YY, White CA, Greer YE, Herring LE, Lipkowitz S, Sumner SCJ, Iwanowicz EJ, Graves LM. Fennell EMJ, et al. Among authors: iwanowicz ej. Front Pharmacol. 2023 Mar 31;14:1136317. doi: 10.3389/fphar.2023.1136317. eCollection 2023. Front Pharmacol. 2023. PMID: 37063293 Free PMC article.
Characterization of TR-107, a novel chemical activator of the human mitochondrial protease ClpP.
Fennell EMJ, Aponte-Collazo LJ, Wynn JD, Drizyte-Miller K, Leung E, Greer YE, Graves PR, Iwanowicz AA, Ashamalla H, Holmuhamedov E, Lang H, Karanewsky DS, Der CJ, Houry WA, Lipkowitz S, Iwanowicz EJ, Graves LM. Fennell EMJ, et al. Among authors: iwanowicz ej. Pharmacol Res Perspect. 2022 Aug;10(4):e00993. doi: 10.1002/prp2.993. Pharmacol Res Perspect. 2022. PMID: 35929764 Free PMC article.
Correction to "Mitochondrial Protease ClpP Is a Target for the Anticancer Compounds ONC201 and Related Analogues".
Graves PR, Aponte-Collazo LJ, Fennell EMJ, Graves AC, Hale AE, Dicheva N, Herring LE, Gilbert TSK, East MP, McDonald IM, Lockett MR, Ashamalla H, Moorman NJ, Karanewsky DS, Iwanowicz EJ, Holmuhamedov E, Graves LM. Graves PR, et al. Among authors: iwanowicz ej. ACS Chem Biol. 2022 Aug 19;17(8):2377-2378. doi: 10.1021/acschembio.2c00545. Epub 2022 Jul 25. ACS Chem Biol. 2022. PMID: 35878877 Free PMC article. No abstract available.
Potent ClpP agonists with anticancer properties bind with improved structural complementarity and alter the mitochondrial N-terminome.
Mabanglo MF, Wong KS, Barghash MM, Leung E, Chuang SHW, Ardalan A, Majaesic EM, Wong CJ, Zhang S, Lang H, Karanewsky DS, Iwanowicz AA, Graves LM, Iwanowicz EJ, Gingras AC, Houry WA. Mabanglo MF, et al. Among authors: iwanowicz ej. Structure. 2023 Feb 2;31(2):185-200.e10. doi: 10.1016/j.str.2022.12.002. Epub 2022 Dec 30. Structure. 2023. PMID: 36586405 Free PMC article.
Mitochondrial Protease ClpP is a Target for the Anticancer Compounds ONC201 and Related Analogues.
Graves PR, Aponte-Collazo LJ, Fennell EMJ, Graves AC, Hale AE, Dicheva N, Herring LE, Gilbert TSK, East MP, McDonald IM, Lockett MR, Ashamalla H, Moorman NJ, Karanewsky DS, Iwanowicz EJ, Holmuhamedov E, Graves LM. Graves PR, et al. Among authors: iwanowicz ej. ACS Chem Biol. 2019 May 17;14(5):1020-1029. doi: 10.1021/acschembio.9b00222. Epub 2019 May 1. ACS Chem Biol. 2019. PMID: 31021596 Free PMC article.
Novel diamide-based inhibitors of IMPDH.
Gu HH, Iwanowicz EJ, Guo J, Watterson SH, Shen Z, Pitts WJ, Dhar TG, Fleener CA, Rouleau K, Sherbina NZ, Witmer M, Tredup J, Hollenbaugh D. Gu HH, et al. Among authors: iwanowicz ej. Bioorg Med Chem Lett. 2002 May 6;12(9):1323-6. doi: 10.1016/s0960-894x(02)00132-4. Bioorg Med Chem Lett. 2002. PMID: 11965381
Identification of novel and potent isoquinoline aminooxazole-based IMPDH inhibitors.
Chen P, Norris D, Haslow KD, Murali Dhar TG, Pitts WJ, Watterson SH, Cheney DL, Bassolino DA, Fleener CA, Rouleau KA, Hollenbaugh DL, Townsend RM, Barrish JC, Iwanowicz EJ. Chen P, et al. Among authors: iwanowicz ej. Bioorg Med Chem Lett. 2003 Apr 7;13(7):1345-8. doi: 10.1016/s0960-894x(03)00107-0. Bioorg Med Chem Lett. 2003. PMID: 12657279
28 results